Carl Icahn Laboratory on Muck Rack

Carl Icahn Laboratory

As seen in: Genome Biology, Cell Press
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Articles

Inference of Multisite Phosphorylation Rate Constants and Their Modulation by Pathogenic Mutations

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By Eyan Yeung, Carl Icahn Laboratory, Washington Road, Lewis Thomas Laboratory
| Cell Press Verified
Highlights • A 3-parameter model compactly captures the kinetic features of dual phosphorylation • ERK dual phosphorylation by wild-type MEK is partially processive in vitro • MEK E203K, a cancer mutation, increases the processivity of ERK phosphorylation • MEK Y130C and F53S mutations increase the rate of MEK activation Summary Multisite protein phosphorylation plays a critical role in cell regulation [, 2 Kageyama H. Kondo T. Iwasaki H.
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The long walk to African genomics

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By Serena Tucci, Joshua M. Akey, Carl Icahn Laboratory
| Genome Biology Verified
Research Highlight Open Access Published: 27 June 2019 Genome Biology volume 20, Article number: 130 (2019) Cite this article 6576 Accesses 7 Citations 69 Altmetric Metrics details African populations are underrepresented in genetics research, but two recent studies describing high-coverage whole-genome sequence data have provided new insights into African genetic diversity and population history.
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