Carla Isabel Wittern on Muck Rack

Carla Isabel Wittern

As seen in: The Journal of Biological Chemistry
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Articles

Comprehensive characterization of the OCT1 phenylalanine-244-alanine substitution reveals highly substrate-dependent effects on transporter function

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By Sophie Schroder, Jürgen Brockmöller, Lukas Gebauer, Carla Isabel Wittern
| The Journal of Biological Chemistry Verified
Keywords Site-directed mutagenesis organic cation transporter 1 polyspecificity transport inhibition alanine mutagenesis binding pocket Abbreviations ASP+ (4-(4-(dimethylamino)styryl)-N-methylpyridinium) BSA (bovine serum albumin) Cryo-EM (cryogenic electron microscopy) D-PBS (Dulbecco’s phosphate buffered saline) DMEM (Dulbecco’s Modified Eagle’s Medium) FCS (fetal calf serum) HBSS (Hanks balanced salt solution) HEK293 (human embryonic kidney 293 cells) HPLC (high performance liquid...
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