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Carmit Bar on Muck Rack

Carmit Bar

As seen in: Cell Press
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Articles

UV-induced reduction in Polycomb repression promotes epidermal pigmentation

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By Pooja Flora, Carmit Bar, Jose Silva, Meng-Yen Li
| Cell Press Verified
Highlights • Polycomb repression is reduced in the epidermis upon low-dose UV exposure • Loss of Polycomb repression in the epidermis results in epidermal pigmentation • Polycomb controls epidermal pigmentation via a p53-independent pathway • Type II collagen promotes UV-induced epidermal pigmentation Summary Ultraviolet (UV) radiation is a prime environmental stressor that our epidermis is exposed to on a daily basis.
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Polycomb Repressive Complex 1 Controls Maintenance of Fungiform Papillae by Repressing Sonic Hedgehog Expression

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By Idan Cohen, Albert Einstein College, Carmit Bar, Dejian Zhao
| Cell Press Verified
Highlights • PRC1 is critical for lingual papillae development, while PRC2 is dispensable • PRC1 ablation results in ectopic SHH signaling and taste cell niche collapse • Ablation of SHH signaling in PRC1-null tongues rescues taste cell cluster integrity • Spatial gene regulation in the non-gustatory niche is essential for taste cells Summary How tissue patterns are formed and maintained are fundamental questions.
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