Caroline Doherty on Muck Rack

Caroline Doherty

As seen in: BU Pipe Dream, Wiley Online Library, MDPI, JAMA (The Journal of the American Medical Association), JAMA: Journal of the American Medical Association, Irish Independent, Cell Press
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Articles

An Unbiased Cell‐Culture Selection Yields DNA Aptamers as Novel Senescent Cell‐Specific Reagents

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By Keenan Pearson, Sarah K. Jachim, Caroline Doherty, Brandon Wilbanks
| Wiley Online Library Verified
1 Introduction Cellular senescence is a state of irreversible cell cycle arrest, first characterized by Hayflick and Moorhead (1961). Since that time, there has been extensive research to characterize mechanisms of senescence induction, the role of senescence in tissue remodeling, its anti-tumorigenesis function, its contribution to age-related diseases, and biomarkers to more specifically define senescent cells (Dodig et al. 2019; Hernandez-Segura et al. 2018; Munoz-Espin and Serrano 2014).
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An unbiased cell-culture selection yields DNA aptamers as novel senescent cell-specific reagents

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By Keenan Pearson, Sarah K. Jachim, Caroline Doherty, Brandon Wilbanks
| biorxiv.org
Abstract Cellular senescence is an irreversible form of cell-cycle arrest caused by excessive stress or damage. While various biomarkers of cellular senescence have been proposed, there are currently no universal, stand-alone indicators of this condition. The field largely relies on the combined detection of multiple biomarkers to differentiate senescent cells from non-senescent cells.
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Mammalian oocytes receive maternal-effect RNAs from granulosa cells

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By Steven C. Munger, Caroline Doherty, Diana J. Laird, Abdulfatai Tijani
| biorxiv.org
Abstract It is currently thought that growing mammalian oocytes receive only small molecules via gap junctions from surrounding support cells, the granulosa cells. From the study of chimeric preantral oocyte and granulosa cell reaggregations, we provide evidence that growing mouse oocytes receive mRNAs from granulosa cells. Among the >1,000 granulosa-transcribed RNAs we identified in the oocyte, those that contribute to proper oocyte maturation and early embryo development were highly enriched.
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