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Cathelijn E.M. Aarts on Muck Rack

Cathelijn E.M. Aarts

As seen in: Cell Press
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Articles

Dynamic Transcriptome-Proteome Correlation Networks Reveal Human Myeloid Differentiation and Neutrophil-Specific Programming

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By Farzin Pourfarzad, Sanquin Research, Arie J. Hoogendijk, Cathelijn E.M. Aarts
| Cell Press Verified
Highlights • Dissection of transcriptome-proteome networks underlying neutrophil differentiation • Distinct patterns of RNA-protein kinetics correlate with biological processes • Discordant dynamics allows for functional annotation of granule proteins • Anabolic collapse paradoxically coincides with gain in neutrophil function Summary Human neutrophilic granulocytes form the largest pool of innate immune cells for host defense against bacterial and fungal pathogens.
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