Cátia Fortunato

Keywords neuropixels striatum motor cortex motor control reinforcement learning action specification action selection basal ganglia optogenetics computational model Introduction Mammals have multi-jointed limbs with many degrees of freedom, enabling highly flexible, complex, and dexterous actions.

Keywords neuropixels striatum motor cortex motor control reinforcement learning action specification action selection basal ganglia optogenetics computational model Introduction Mammals have multi-jointed limbs with many degrees of freedom, enabling highly flexible, complex, and dexterous actions.

Abstract The interplay between two major forebrain structures - cortex and subcortical striatum - is critical for flexible, goal-directed action. Traditionally, it has been proposed that striatum is critical for selecting what type of action is initiated while the primary motor cortex is involved in the online control of movement execution. Recent data indicates that striatum may also be critical for specifying movement execution.