Célia Scribe on Muck Rack

Célia Scribe

As seen in: Nature
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Aging affects reprogramming of pulmonary capillary endothelial cells after lung injury in male mice - Nature Communications

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By Marine Gautier-Isola, Marie-Jeanne Arguel, Nathalie Martin, Roger Rezzonico, Charles-Hugo Marquette, Paul Hofman, Andreas Günther, Nicolas Ricard, Pascal Barbry, Kevin Lebrigand, Georges Vassaux, Nicolas Pottier, Célia Scribe, Virginie Magnone
| Nature
Abstract Aging increases the risk of developing fibrotic diseases by hampering tissue regeneration after injury. Using longitudinal single-cell RNA-seq and spatial transcriptomics, here we compare the transcriptome of bleomycin (BLM) -induced fibrotic lungs of young and aged male mice, at 3 time points corresponding to the peak of fibrosis, regeneration, and resolution. We find that lung injury shifts the transcriptomic profiles of three pulmonary capillary endothelial cells (PCEC) subpopulations.
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