Celina Sanchez

ArticleVolume 86, Issue 4p640-655.e6Open access Affiliations & Notes 1Cancer Early Detection Advanced Research Center, Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA 2Program in Biomedical Sciences, School of Medicine, Oregon Health and Science University, Portland, OR, USA 3Institute of Epigenetics and Stem Cells, Helmholtz Munich, 81377 Munich, Germany 4Division of Oncological Sciences, Knight Cancer Institute, Oregon Health and Science University,...

Abstract Chromatin is organized into compartments enriched with functionally related proteins driving non-linear biochemical activities. Some compartments, e.g. transcription foci, behave as liquid condensates. While the principles governing the enrichment of proteins within condensates are being elucidated, mechanisms that coordinate condensate dynamics with other nuclear processes like DNA replication have not been identified.