Cerrone Cabanos

Abstract Many proteins must translocate through the protein-conducting Sec61 channel in the eukaryotic endoplasmic reticulum membrane or the SecY channel in the prokaryotic plasma membrane1,2. Proteins with hydrophobic signal sequences are first recognized by the signal recognition particle (SRP)3,4 and then moved co-translationally through the Sec61/SecY channel by the associated translating ribosome.

Soybean is a major food allergen in children. Component‐resolved diagnostics has improved the accuracy of diagnosing immunoglobulin E (IgE)‐mediated food allergies. We aimed to develop a novel component for the diagnosis of soybean allergy using recombinant technology. Japanese paediatric patients with suspected soybean allergy (n = 91) were included, and symptomatic (n = 40) and asymptomatic (n = 51) cases were divided through oral food challenge testing.

To determine whether PG, PA, and PIP are TREK-1 agonists or antagonists, we tested ion conductance in a flux assay (Brohawn et al., 2012xCrystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel. Brohawn, S.G., del Mármol, J., and MacKinnon, R. Science. ; 335: 436–441 Crossref | PubMed | Scopus (171)See all ReferencesBrohawn et al., 2012). PA and PG are both products of the enzyme PLD2 (Yang et al., 1967xTransphosphatidylation by phospholipase D.