Chahat Upreti on Muck Rack

Chahat Upreti

As seen in: Cell Host & Microbe
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Articles

Long-lasting gut microbiome and fecal metabolome alterations after colorectal adenoma removal and their relationship to colorectal cancer

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By Ana Nogal, Kai Wang, Kelsey Thompson , Hanseul Kim, Amrisha Bhosle, Gianmarco Piccinno, Chahat Upreti, Long Nguyen, Long Nguyễn, Nicola Segata, Eric B. Rimm, Wendy S. Garrett, Andrew Chan, Curtis Huttenhower, Mingyang Song, Sagun Maharjan
| Cell Host & Microbe
Keywords colorectal cancer adenoma resection gut microbiome fecal metabolome adenoma-carcinoma continuum metagenomics Introduction Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide.1 Most CRC cases arise from dysplastic adenomas, which can progress to CRC through the adenoma-carcinoma sequence.1 This sequence typically takes an average of 17 years and is characterized by the accumulation of specific mutations alongside morphological changes.2 As a...
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CRISPR-Cas inhibits plasmid transfer and immunizes bacteria against antibiotic resistance acquisition in manure

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By Pranav Kumar, Lisa M. Durso, Kelli Palmer, Chahat Upreti
| biorxiv.org
Abstract The horizontal transfer of antibiotic resistance genes among bacteria is a pressing global issue. The bacterial defense system CRISPR-Cas acts as a barrier to the spread of antibiotic resistance plasmids, and CRISPR-Cas-based antimicrobials can be effective to selectively deplete antibiotic-resistant bacteria.
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