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Chaille Webb on Muck Rack

Chaille Webb

As seen in: Nature
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Articles

Uncovering an alternate pathway of antibiotic resistance in spore-forming bacteria

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By Yogitha N. Srikhanta, Clara E. Bate, Sarah A. Revitt-Mills, Galain C. Williams, Sophie Day Verified, Stéphane Mesnage, Kamila Kochan, Shailab Shrestha, Aimee Shen, Daniel Knight, Korakrit Imwattana, Thomas Riley, Kimberley Bourke, Milena M. Awad, Caroline Evans, Ghizal Siddiqui, Joel Steele, David L. Steer, Joshua P. Morrow, Darren J. Creek, Sheena McGowan, Dena Lyras, Desirel Ng, Georgia-Rose Gilmore, Irene Alevizos, Chaille Webb
| Nature Verified
Abstract Spore-forming bacteria produce two distinct cell types: vegetative cells and resilient spores. While antibiotic resistance is typically associated with vegetative cells, spores play a critical role in disseminating resistance genes due to their durability and transmissibility. We previously demonstrated that cephamycin antibiotics target the conserved spore-specific protein SpoVD, significantly reducing spore formation in pathogens including Clostridioides difficile.
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