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Shailab Shrestha on Muck Rack

Shailab Shrestha

As seen in: Nature, BioRxiv
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Articles

Uncovering an alternate pathway of antibiotic resistance in spore-forming bacteria

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By Yogitha N. Srikhanta, Clara E. Bate, Sarah A. Revitt-Mills, Galain C. Williams, Sophie Day Verified, Stéphane Mesnage, Kamila Kochan, Shailab Shrestha, Aimee Shen, Daniel Knight, Korakrit Imwattana, Thomas Riley, Kimberley Bourke, Milena M. Awad, Caroline Evans, Ghizal Siddiqui, Joel Steele, David L. Steer, Joshua P. Morrow, Darren J. Creek, Sheena McGowan, Dena Lyras, Desirel Ng, Georgia-Rose Gilmore, Irene Alevizos, Chaille Webb
| Nature Verified
Abstract Spore-forming bacteria produce two distinct cell types: vegetative cells and resilient spores. While antibiotic resistance is typically associated with vegetative cells, spores play a critical role in disseminating resistance genes due to their durability and transmissibility. We previously demonstrated that cephamycin antibiotics target the conserved spore-specific protein SpoVD, significantly reducing spore formation in pathogens including Clostridioides difficile.
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Functional redundancy between penicillin-binding proteins during asymmetric cell division in Clostridioides difficile

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By Shailab Shrestha, Jules M. Dressler, Gregory Harrison, Morgan E. McNellis
| BioRxiv
Abstract Peptidoglycan synthesis is an essential driver of bacterial growth and division. The final steps of this crucial process involve the activity of the SEDS family glycosyltransferases that polymerize glycan strands and the class B penicillin-binding protein (bPBP) transpeptidases that cross-link them.
Open in Who Shared Issue with article?

Penicillin-binding proteins exhibit catalytic redundancy during asymmetric cell division in Clostridioides difficile

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By Shailab Shrestha, Jules M. Dressler, Morgan E. McNellis, Aimee Shen
| BioRxiv
Abstract Peptidoglycan synthesis is an essential driver of bacterial growth and division. The final steps of this crucial process involve the activity of SEDS family glycosyltransferases that polymerize glycan strands and class B penicillin-binding protein (bPBP) transpeptidases that cross-link them.
Open in Who Shared Issue with article?
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