Chak Lam Chan on Muck Rack

Chak Lam Chan

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Articles

mTOR-driven integrin β4-enriched extracellular vesicles from lenvatinib-resistant hepatocellular carcinoma fuel lung metastasis via fibroblast-niche formation

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By Tiantian Zou, Xufeng Wang, Haoting Sun, Beiyuan Hu, Jianhua Li, Yu Guo, Zilu Tian, Hao Xu, Yan Zheng, Le Zhu, Keyu Shen, Xiaotian Shen, Qiongzhu Dong, Lun-Xiu Qin, Yinghan Su, Chak Lam Chan
| Nature Verified
Abstract Tumor-derived extracellular vesicles (EVs) play crucial roles in facilitating the colonization and growth of metastatic cancer cells in distant organs. Nevertheless, the precise mechanisms by which EVs contribute to therapy-resistant cancer dissemination remain poorly understood.
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