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Yinghan Su

As seen in: Nature
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Articles

SCAMP3: a two-front driver of hepatocellular carcinoma via YAP activation and extracellular vesicle export

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By Xiangdong Wang, Jie Shi, Haihua Qian, Liang Wang, Qianni Zong, Hongwei Lv, Guishuai Lv, Bin Sun, Yinghan Su, Longyi Zheng, Chunying Liu, Xuejing Lin
| Nature Verified
Abstract Single-cell transcriptomic analysis of primary hepatocellular carcinoma (HCC) revealed that SCAMP3 is predominantly expressed in metabolically aberrant malignant hepatocyte clusters. Despite its known roles in vesicle transport and extracellular microenvironment regulation, the comprehensive function of SCAMP3 in HCC progression has been largely overlooked.
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mTOR-driven integrin β4-enriched extracellular vesicles from lenvatinib-resistant hepatocellular carcinoma fuel lung metastasis via fibroblast-niche formation

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By Tiantian Zou, Xufeng Wang, Haoting Sun, Beiyuan Hu, Jianhua Li, Yu Guo, Zilu Tian, Hao Xu, Yan Zheng, Le Zhu, Keyu Shen, Xiaotian Shen, Qiongzhu Dong, Lun-Xiu Qin, Yinghan Su, Chak Lam Chan
| Nature Verified
Abstract Tumor-derived extracellular vesicles (EVs) play crucial roles in facilitating the colonization and growth of metastatic cancer cells in distant organs. Nevertheless, the precise mechanisms by which EVs contribute to therapy-resistant cancer dissemination remain poorly understood.
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