Challana Tea

Abstract The dysregulation of chromatin organization has been associated with numerous forms of neurological disease. In the ANAPC7 neurodevelopmental syndrome, a disease mechanistically linked to defective proteasomal degradation, the mitotic protein Ki-67 accumulates abnormally in heterochromatin compartments. Here, we investigate Ki-67’s role in heterochromatin through in vivo examination of neurons from two relevant genetic mouse models, in vitro assays and computational studies.

4D mitochondrial network tracking shows drug-dependent network remodeling rates, network transport, and network resilience 4D mitochondrial network tracking allowed us to investigate the mitochondrial network from the perspective of a temporal network (Fig 6a). Specifically, it is now possible to quantify a) remodeling of the mitochondrial network, b) flux across the network as it moves spatially and is being remodeled, and c) resilience of the network to damage. Fig 6.