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Chandana Barat on Muck Rack

Chandana Barat

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Articles

Tau protein- induced sequestration of the eukaryotic ribosome: Implications in neurodegenerative disease

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By Amar Nath Ghosh, Senjuti Banerjee, Sehnaz Ferdosh, Chandana Barat
| Nature Verified
Abstract The human tau is a microtubule-associated intrinsically unstructured protein that forms intraneuronal cytotoxic deposits in neurodegenerative diseases, like tauopathies. Recent studies indicate that in Alzheimer’s disease, ribosomal dysfunction might be a crucial event in the disease pathology. Our earlier studies had demonstrated that amorphous protein aggregation in the presence of ribosome can lead to sequestration of the ribosomal components.
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