Changlin Yin

Abstract This study aims to evaluate the relationship between triglyceride-glucose (TyG) index variability and in-hospital mortality across two intensive care unit (ICU) databases (MIMIC-IV and SWH) and to determine if TyG variability provides more prognostic value than baseline TyG. This retrospective observational study utilized data from the MIMIC-IV (2008–2019) and SWH (2016–2023) ICU cohorts.

1 Introduction X-linked adrenoleukodystrophy (ALD) is a rare genetic disease caused by mutations in the ATP-binding cassette subfamily D member 1 (ABCD1) gene (Mares Beltran et al., 2024). This gene encodes a peroxisomal membrane protein, which is critical for transporting very long-chain fatty acids (VLCFAs) for beta-oxidation (Buda et al., 2023). Mutations in the ABCD1 gene disrupt the metabolism of VLCFAs, which leads to damage in the adrenal glands and brain white matter (Launay et al., 2024).

1. Introduction Spatial planning has played a crucial role in China’s rapid urbanization, promoting the sustainable use and adequate protection of national land. However, spatial planning in China faces challenges, such as excessive planning types, overlaps and conflicts, resulting from the involvement of multiple management entities [1]. To address these issues, spatial planning must ensure the legality, uniformity, authority, and relevance of data.