Yinglian Chen

1 Introduction X-linked adrenoleukodystrophy (ALD) is a rare genetic disease caused by mutations in the ATP-binding cassette subfamily D member 1 (ABCD1) gene (Mares Beltran et al., 2024). This gene encodes a peroxisomal membrane protein, which is critical for transporting very long-chain fatty acids (VLCFAs) for beta-oxidation (Buda et al., 2023). Mutations in the ABCD1 gene disrupt the metabolism of VLCFAs, which leads to damage in the adrenal glands and brain white matter (Launay et al., 2024).

Abstract Precise determination of dissolved phosphorus concentration in antibiotic fermentation broths is essential for microbial growth and metabolism during fermentation. The conventional method often relies on manual operations, leading to low reproducibility. Herein, we applied the phosphomolybdenum blue reaction to flow injection analysis (FIA) to create an automated approach for phosphorus quantification in antibiotic fermentation broths.