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Hypothalamic malate dehydrogenase 2 modulates systemic glucose metabolism through oxytocin-mediated thermogenesis
Keywords malate dehydrogenase 2 MDH2 hypothalamus oxytocin metabolic surgery brown adipose tissue BAT type 2 diabetes T2D sympathetic nervous system SNS Introduction Obesity and type 2 diabetes (T2D) are among the most prevalent chronic metabolic disorders worldwide, severely impacting health and reducing quality of life. Although numerous pharmacological interventions have been developed, safe and effective long-term treatments remain limited.
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