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Tiemin Liu

As seen in: Nature, MDPI, Cell Metabolism, Cell Reports, Cell Reports Medicine, medRxiv, Texas Medical Center
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Articles

Hypothalamic malate dehydrogenase 2 modulates systemic glucose metabolism through oxytocin-mediated thermogenesis

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By Ting Yao, Guoming Wu, Yu Zeng, Yinyin Xie, Xiao Cui, Qiongyue Zhang, Zhicheng Cui, Hongyu Gong, Xian Liang, Yan Zhang, Ruiqi Zheng, Hui Wang, Mingchun Gao, Peng Zhang, Ru Wang, Xiao Zhao, Zhihui Feng, Lei Xiao, Tiemin Liu, Zhi Zhang, Chaoying Yan, Tianze Xiong
| Cell Reports Medicine Verified
Keywords malate dehydrogenase 2 MDH2 hypothalamus oxytocin metabolic surgery brown adipose tissue BAT type 2 diabetes T2D sympathetic nervous system SNS Introduction Obesity and type 2 diabetes (T2D) are among the most prevalent chronic metabolic disorders worldwide, severely impacting health and reducing quality of life. Although numerous pharmacological interventions have been developed, safe and effective long-term treatments remain limited.
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Time-restricted feeding provides limited microglial immunometabolic improvements in diet-induced obese rats

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By Han Jiao, Jarne Jermei, Xian Liang, Frank Vrieling, Valentina Sophia Rumanova, Anhui Wang, Ewout Foppen, Bob Ignacio, Dirk Jan Stenvers, Tiemin Liu, Kimberly M Bonger, Rinke Stienstra, Zhi Zhang, Andries Kalsbeek, Chun-Xia Yi, Milan Dorscheidt
| Cell Reports Verified
Keywords microglia time-restricted feeding circadian rhythm obesity immunometabolism Research topic(s) CP: Metabolism CP: Immunology Introduction Time-restricted feeding (TRF) has emerged as a dietary intervention that improves metabolic health and reduces the adverse effects of the high-fat diet (HFD) by aligning food intake with the endogenous circadian timing system.1,2,3 In nocturnal animals, such as rats, consuming food during the active dark phase is hypothesized to enhance circadian...
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The Hypothalamus for Whole-Body Physiology: From Metabolism to Aging

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By Tiemin Liu
| Texas Medical Center
Publication Date 6-1-2022 DOI 10.1007/s13238-021-00834-x PubMedCentral® Posted Date 4-7-2021 PubMedCentral® Full Text Version Post-print Published Open-Access yes Keywords Aging, Brain, Energy Metabolism, Humans, Hypothalamus, Obesity, neuron, metabolism, hypothalamus, obesity, aging Abstract Obesity and aging are two important epidemic factors for metabolic syndrome and many other health issues, which contribute to devastating diseases such as cardiovascular diseases, stroke and cancers.
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