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Chari L. Cortez on Muck Rack

Chari L. Cortez

As seen in: Science Magazine, BioRxiv
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Articles

Identification of amnion progenitor-like cells at the amnion-epiblast boundary in the primate peri-gastrula

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By Nikola Sekulovski, Chari L. Cortez, Michael Czerwinski, Lauren L Juga
| BioRxiv
Abstract Amniogenesis is triggered in a collection of pluripotent epiblast cells as the human embryo implants. To gain insights into the critical but poorly understood transcriptional machinery governing amnion fate determination, we examined the evolving transcriptome of a developing human pluripotent stem cell-derived amnion model at the single cell level.
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Spatially resolved cell polarity proteomics of a human epiblast model

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By Sicong Wang, Chien-Wei Lin, Amber E. Carleton, Chari L. Cortez
| Science Magazine Verified
Abstract Critical early steps in human embryonic development include polarization of the inner cell mass, followed by formation of an expanded lumen that will become the epiblast cavity. Recently described three-dimensional (3D) human pluripotent stem cell–derived cyst (hPSC-cyst) structures can replicate these processes.
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