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Chien-Wei Lin

As seen in: Nature, Wiley Online Library, MDPI, SAGE Publishing, Genome Biology, Science Magazine, BioRxiv, Amazon Science
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Articles

Dialog simulation with realistic variations for training goal-oriented conversational systems

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By Chien-Wei Lin, Vincent Auvray, Daniel Elkind
| Amazon Science
Goal-oriented dialog systems enable users to complete specific goals like requesting information about a movie or booking a ticket. Typically the dialog system pipeline contains multiple ML models, including natural language understanding, state tracking and action prediction (policy learning). These models are trained through a combination of supervised or reinforcement learning methods and therefore require collection of labeled domain specific datasets.
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Paxillin in mechanosensitive spatial control of lung endothelial cell regeneration

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By Tadanori Mammoto, Elaheh Hashemi, Xiaolong Ma, Christopher Turner, Chien-Wei Lin, Subramaniam Malarkannan, Akiko Mammoto, Priscilla Kyi, Mikaela Scheer, Tendai Hunyenyiwa
| Nature Verified
Abstract Mechanical forces altered after unilateral pneumonectomy (PNX) control post-PNX lung growth. Here, we demonstrate that post-PNX endothelial regeneration is stimulated at the peripheral region of the mouse lung, requiring the focal adhesion (FA) protein, paxillin, while inhibition of mechanical tension attenuates the effects.
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Single-cell transcriptomics reveals FXR1 as an actionable target for siRNA therapy in ovarian cancer

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By Jasmine George, Xiaolong Ma, Ishaque Pulikkal Kadamberi, Ajay Nair Verified, Sonam Mittal, Sudhir Kumar, Mona Singh, Anjali Geethadevi, Meenakshi Pradeep, Anupama Nair, Shirng-Wern Tsaih, Julie M. Jorns, Subramaniam Malarkannan, Felix Dietlein, Chien-Wei Lin, Sunila Pradeep, Pradeep Chaluvally-Raghavan, Elaheh Hashemi
| Nature Verified
Abstract Ovarian cancer is one of the leading causes of cancer-related mortality among women and remains exceptionally difficult to manage and treat effectively in the clinic. Fragile X-related protein 1 (FXR1) is highly amplified and overexpressed in ovarian and several other cancers. FXR1 is a key regulator of the translation of multiple oncogenes and therefore represents a vulnerable target for cancer therapy.
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