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Cancer, Liver April 6, 2022 | Robin Stanley Receiving a diagnosis of colorectal liver metastases can be frightening. But can it be cured? The answer might surprise you. Hartford HealthCare’s Jocelyn Maminta recently spoke with surgical oncologist Dr. Charles Cha with the Cancer Institute at St. Vincent’s Medical Center in Bridgeport about treatment options when colon cancer spreads to the liver.
Highlights • Renalase (RNLS) knockout in immune cells substantially inhibits tumour growth. • Anti-RNLS antibodies enhance effects of anti-programmed cell death protein 1 (PD-1) in melanoma-bearing mice. • T cells (but not MØ) are required for anti-RNLS effects on tumours. • Immunotherapy-treated patients with melanoma with high tumour RNLS have worse survival. • Anti-RNLS antibodies might have therapeutic value in anti-PD-1–resistant melanomas.
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