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Yuval Kluger on Muck Rack

Yuval Kluger

New Haven
As seen in: Nature, PLOS, MDPI, BioRxiv, Cell Reports Medicine, Cell Press, Archives of Pathology, European Journal of Cancer
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Articles

A spatial multi-omics atlas of immunosenescence reveals germinal-center B cell alteration in human lymph nodes

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By Negin Farzad, Archibald Enninful, Yao Lu Verified, Fabio Parisi, Anthony Fung, Yumi Kwon, yajuan Li, Mingyu Yang, Francesco Strino, Liang Chen, Junchen Yang, Mei Zhong, Fu Gao, Bo Tao, Joseph Cunningham, Zhiliang Bai, Haikuo Li, Fang Wang, Michael C Stankewich, Dongjoo Kim, Mingze Dong, Lisa M. Bramer, Keyi LI, Meera Bhat, Joseph Craft, Ljiljana Paša-Tolić, Stephanie Halene, Lingyan Shi, Yuval Kluger, Mina L. Xu, Rong Fan, Margaux Labrosse, Evan J. Loe
| Cell Press Verified
To investigate senescence-associated and age-related changes in human LNs, we analyzed whole LN resections or needle biopsy tissue blocks from 65 donors (41 males and 24 females; 108 total samples) obtained through the Yale Pathology Tissue Service. LN tissue samples were stratified into three age groups: group 1 (<50 years, n = 26), group 2 (50–69 years, n = 15), and group 3 (≥70 years, n = 10), with median ages of 32, 56, and 75 years, respectively (Figures 1 and S1; Table S1).
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Nerve-associated macrophages control adipose homeostasis across lifespan and restrain age-related inflammation - Nature Aging

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By Keyi LI, Sviatoslav Sidorov, Christina D. Camell, Maxim N. Artyomov, Yuval Kluger, Kamal M. Khanna
| Nature Verified
Abstract Age-related inflammation or ‘inflammaging’ increases disease burden and controls lifespan. Adipose tissue macrophages (ATMs) are critical regulators of inflammaging; however, the mechanisms involved are not well understood in part because the molecular identities of niche-specific ATMs are unknown.
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Humoral determinants of checkpoint immunotherapy - Nature

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By Yile Dai, Yuval Kluger, Kevan C Herold, Harriet M Kluger, Leon Furchtgott
| Nature Verified
Abstract Although the role of cellular immunity in checkpoint immunotherapy (CPI) for cancer is well established1,2, the effect of antibody-mediated humoral immunity is comparably underexplored. Here we used rapid extracellular antigen profiling3 to map the autoantibody reactome within a cohort of 374 patients with cancer treated with CPIs and 131 healthy control participants for autoantibodies to 6,172 extracellular and secreted proteins (the ‘exoproteome’).
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