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Charmaine Chia on Muck Rack

Charmaine Chia

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Articles

Kinetic Activity Profiling of Galactose Oxidase Mutants for Biocatalytic Secondary Alcohol Oxidation

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By Dillon Tay, Ying Sin Koo, Jhoann M. T. Miyajima, Shreyas Supekar, Hao Fan, Sebastian Maurer-Stroh, Ee Lui Ang, Charmaine Chia, Nazreen Abdul Muthaliff, Tong Mei Teh
| Nature Verified
Abstract Biocatalysis provides a sustainable approach for highly selective chemical transformations, however the complex, non-additive nature of enzyme fitness landscapes remains a significant barrier hindering the predictive design of optimized enzymes. Here, we document a curated dataset of kinetic colorimetric activity measurements of galactose oxidase variants for biocatalytic oxidation of a secondary alcohol, 1-phenylbutan-1-ol.
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