Chelsea McLean

Abstract Adenovirus 26 (Ad26) is frequently used as a vaccine vector targeting infectious diseases. Neutralizing antibodies (NAbs) induced by natural infection or immunization against some viral vaccine vectors may impact vaccine-induced immunogenicity and efficacy. We evaluated the natural seroprevalence and impact of Ad26 NAbs on vaccine immunogenicity using data combined from 21 clinical studies including 3851 participants from 15 countries.

Abstract Vaccines targeting the conserved stem region of influenza hemagglutinin (HA) may induce broad immunity and reduce reliance on strain-matched seasonal formulations. This Phase 1/2a study evaluates safety and immunogenicity of a universal influenza vaccine component comprising a soluble trimeric stabilized group 1 HA-stem protein (INFLUENZA G1 mHA). Healthy adults aged 18-to-45 received one or two doses at 45 µg or 135 µg, with or without Al(OH)₃.

Abstract Risk of death for both mother and fetus following Ebola virus infection is extremely high. In this study, healthy women in Rwanda aged ≥18 years were randomized to two-dose Ebola vaccination (Ad26.ZEBOV, MVA-BN-Filo) during pregnancy (group A) or postpartum (group B). Unvaccinated pregnant group B women served as control.