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Articles by Chen Lu
ADA2 high tumor cell-derived inosine induces an immunosuppressive microenvironment in gastric cancer by promoting macrophage M2 polarization
Abstract Metabolic alterations within the tumor microenvironment (TME) can reshape the polarization state of tumor-associated macrophages (TAMs) and weaken antitumor immunity, yet the underlying mechanisms remain unclear. In this study, we integrated multiple gastric cancer (GC) single-cell RNA sequencing (scRNA-seq) datasets and identified a tumor cell population with high adenosine deaminase 2 (ADA2) expression that is significantly associated with poor prognosis.
Pairing without γ -pocket in the La 3 Ni 2 O 7 thin film
Abstract High-temperature superconductivity in La3Ni2O7 ultrathin films at ambient pressure, while the γ-pocket previously proposed to be crucial for superconductivity in La3Ni2O7 may not exist in the Fermi surface of the film, raising questions about the pairing mechanism. Using density functional theory + U calculations, we obtain a band structure without the γ-pocket and study pairing via weak- and strong-coupling approaches.
Vision-based human pose estimation for intelligent sports training and teaching assistance
Abstract Vision-based human pose estimation can support intelligent sports training and teaching, but fast motion, motion blur, occlusion, background interference, and computational constraints remain challenging in practical scenarios. This study proposes a sports-oriented framework integrating motion deblurring, target tracking, and a lightweight high-resolution pose estimator termed GSANet.
Classification of magnetism and altermagnetism in quasicrystals
Abstract Altermagnetism (AM), an unconventional magnetic phase characterized by zero net magnetism protected by symmetry(s) other than parity-time (\({\mathcal{P}}{\mathcal{T}}\)) and a resulting spin-split band, has been studied exclusively in crystalline materials. Here, we extend the framework of AM to quasicrystals (QCs).
A Multidentate Coordination Complex-Based Self-Assembled Monolayer Stabilizes Perovskite Interface
Houen Wu and Chen Lu contributed equally to this work. Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement Research data are not shared. Supporting Information Filename Description anie73665-sup-0001-SuppMat.docx13.1 MB Supporting File: anie73665-sup-0001-SuppMat.docx. References 1, , , et al., “Molecular Press Annealing Enables Robust Perovskite Solar Cells,” Science 391 (2026): 164–170, https://doi.org/10.1126/science.aea8228.
Ultralow Power Optoelectronic Reconfigurable Hf 0.2 Zr 0.8 O x -Based Antiferroelectric Device for Adaptive Image Recognition Click to copy article link Article link copied!
Functional Inorganic Materials and DevicesMay 5, 2026 Chen Lu College of Integrated Circuits & Micro-Nano Electronics, School of Microelectronics, Nano Institute of Fudan University, Fudan University, Shanghai 200433, China Pei Liu College of Integrated Circuits & Micro-Nano Electronics, School of Microelectronics, Nano Institute of Fudan University, Fudan University, Shanghai 200433, China Kangli Xu College of Integrated Circuits & Micro-Nano Electronics, School of Microelectronics, Nano...
Ultralow Power Optoelectronic Reconfigurable Hf 0.2 Zr 0.8 O x -Based Antiferroelectric Device for Adaptive Image Recognition Click to copy article link Article link copied!
Cite Jump to ExpandCollapse Functional Inorganic Materials and DevicesMay 5, 2026 Ultralow Power Optoelectronic Reconfigurable Hf0.2Zr0.8Ox-Based Antiferroelectric Device for Adaptive Image Recognition Click to copy article linkArticle link copied! Chen Lu Chen Lu College of Integrated Circuits & Micro-Nano Electronics, School of Microelectronics, Nano Institute of Fudan University, Fudan University, Shanghai 200433, China Pei Liu Pei Liu College of Integrated Circuits & Micro-Nano...
Accelerating spiking neural networks with photonic reconfigurable devices
Abstract Spiking neural networks face hardware limitations as conventional architectures exhibit low array utilization, underperforming GPU-driven artificial neural networks in vision tasks. We present a programmable spiking neurocomputing architecture using CMOS-compatible photonic reconfigurable devices that unify synaptic/neuronal functions in single components.
Numerical simulations for underground hydrogen storage in depleted gas reservoirs
Keywords underground hydrogen storage depleted gas reservoir hydraulic fracture morphology numerical simulation directional well horizontal well Introduction Hydrogen (H2) storage technology plays a crucial role in the global energy landscape. As a clean and sustainable energy carrier, H2 is considered an ideal alternative to traditional fossil fuels.
Alibaba's Qwen to unveil AI glasses, expand into wearables
by SHEN Xiaoge, CHEN Lu Alibaba Group Holding Ltd. will launch its first AI-powered smart glasses under the Qwen brand at the 2026 Mobile World Congress (MWC) in Barcelona on Feb. 27, as Chinese and U.S. technology firms race to secure ground in AI hardware. Pre-orders will open on March 2 across online and offline channels, according to information obtained by Jiemian News.
Fibre integrated circuits by a multilayered spiral architecture
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Abstract Fibre electronic devices are transforming traditional fibres and garments into new-generation wearables that can actively interact with human bodies and the environment to shape future life1,2,3,4,5. Fibre electronic devices have achieved almost all of the desired functions, such as powering6,7, sensing8,9 and display10,11 functions.
By Zhen Wang, Ke Chen, Xiang Shi, Pengzhou Li, Li Yong, Xiao Sun, Ning WANG, Xuemeng Hu, Chen Lu, Chengqiang Tang, Liyuan Wang, Yuanyuan Zheng, Yichi Zhang, Hongyu Guo, Zhaofangzhou Pu, Xiaokun Wang, Yanan Zhang, Haibo Jiang, Yue Liu, Zhihang Tang, Lingsen You, Jue Deng, Renchao Che, Yue Gao, Songlin Zhang, Bingjie Wang, Xuemei Sun, Jiajun Qin, Ya Huang, Li Shen, Junbo Ge, Xiaoyang Zeng, Lin Chen, Peining Chen, Huisheng Peng, Qinhao Du, Yulu Ai
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Nature
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Research progress of small molecule protein kinase inhibitors (SMKIs) in the treatment of colorectal cancer: mechanism, application, and future prospects
Abstract Colorectal cancer (CRC) is among the most common malignancies worldwide, and advanced or metastatic disease remains difficult to treat because of tumor heterogeneity, adaptive resistance, pathway redundancy, drug-related toxicity, and limited predictive biomarkers.
Food processing and global trade flows: What are the trends?
By Eriya Chea, Siramane Coulibaly, Mateo Ferrero, Chen Lu, Thomas Verbeet and Erik Wijkström Economies around the world are increasingly adopting public health policies aimed at improving nutrition and reducing the onset of diseases such as heart disease, stroke and diabetes. In parallel, public health agencies and researchers are focusing more and more on whether the processing of foods (through the use of additives, preservatives and flavourings) negatively affects health.
RAID pedagogy: cultivating twenty-first-century skills and EFL competence via low-tech gamification in Chinese universities
ABSTRACT Following China’s rapid economic development and global integration, the demand for English proficiency among Chinese university students has soared. This article introduces RAID pedagogy, a novel EFL teaching approach designed for Chinese university learners to cultivate their twenty-first-century skills and EFL competence.
BM-MSCs mitigate lung injury in a rat model of decompression sickness
Loading metrics Open Access Peer-reviewed Research Article Citation: Lu C, Gu D, Chen H, Chen L, Chen J, Weng Y, et al. (2025) BM-MSCs mitigate lung injury in a rat model of decompression sickness. PLoS One 20(8): e0326618. https://doi.org/10.1371/journal.pone.0326618 Editor: Roland Eghoghosoa Akhigbe, Ladoke Akintola University of Technology, NIGERIA Received: December 7, 2024; Accepted: June 2, 2025; Published: August 21, 2025 Copyright: © 2025 Lu et al.
All-Electrochem-Active Graphite Electrode Enabled by Manipulating Li+ Activity of Inactive Components for High-Energy Batteries
Introduction Click to copy section linkSection link copied! With the continuous development of portable mobile devices and new-energy vehicles, the development of high-energy-density lithium-ion batteries has been promoted. (1−3) At the same time, higher requirements have been put forward for battery performance, which require the development of high-energy-density batteries.
#AmazingChina | A Spring with the scents of Longjing Tea Original
Amidst the green hills of Hangzhou, Xinhua reporter David immersed himself in the centuries-old craft of Longjing tea production. The ancient art now fuels new trends like milk tea innovations, attracting younger consumers with its blend of heritage and modern creativity. Produced by Xinhua Global Service■
Insights into the enhanced electrochemical performance and energy storage mechanism of manganese vanadate cathode for rechargeable aqueous zinc ion batteries
Insights into the enhanced electrochemical performance and energy storage mechanism of manganese vanadate cathode for rechargeable aqueous zinc ion batteries The N-doped reduced graphene oxide sheets wrapped MnV2O6 nanrods composite was designed and prepared by co-precipitation reaction and subsequent calcination method, and delivered stable reversible capacity, low charge transfer resistances and high diffusion coefficients during the Zn2+ insertion and extraction process.
Sustainable Path Analysis of Urban Agglomerations Based on the Spatial Spillover Effect on Air Pollution
Conflicts of Interest The authors declare that they have no conflict of interest. Supporting Information Filename Description clen70009-sup-0001-SuppMat.docx50.8 KB Supporting information References 1, , , and , “Has Urbanization Accelerated PM2.5 Emissions? An Empirical Analysis With Cross-country Data,” China Economic Review 59 (2020): 101381.
Refractory heart failure due to acquired aortic coarctation after total arch replacement: find the right antidote!
Introduction Aortic coarctation with a discrete narrowing of the aorta, accounting for ~5% of congenital heart diseases,1 is an uncommon cause of heart failure. Thereinto, adult-onset acquired aortic coarctation, usually secondary to trauma and atherosclerotic/atheroembolic disease, is much rarer and idiopathic to lead to acute heart failure, and there are only sporadic reports.2-4 Endovascular therapy has been reported in post-traumatic aortic coarctation.
FAM49B drives colorectal cancer progression by stabilizing c‐Myc through NEK9 phosphorylation
CONFLICT OF INTEREST STATEMENT The authors have no conflicts of interest to declare. Supporting Information Filename Description biof2158-sup-0001-Figures.docxWord 2007 document , 1.8 MB Figure S1. Overexpressing FAM49B promotes proliferation of CRC cells. (A, B) CCK-8 detected the proliferation function of SW480 (A) and SW620 cells (B) transfected Flag-FAM49B plasmids.
Lidocaine as a potential therapeutic agent in colorectal cancer: a stu
Back to Journals » OncoTargets and Therapy » Volume 18 Authors Li W, Gao W, Lu C, Ji M, Yin Y, Zhang H, Liu C, Yu C Received 20 November 2024 Accepted for publication 4 June 2025 Published 18 June 2025 Volume 2025:18 Pages 737—749 DOI https://doi.org/10.2147/OTT.S505753 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Nagashree Seetharamu Wenyuan Li,1,* Wenjie Gao,2,* Chen Lu,3,* Muhuo Ji,1 Yuan Yin,1...
A Stepwise‐Clustered Precipitation Downscaling Method for Ensemble Climatic Projections in the Mediterranean Region
1 Introduction The Mediterranean region is one of the benchmark areas to identify the impacts of climate changes on precipitation regimes (Giorgi 2006). This area is composed of 22 countries located in Asia, Europe and Africa, forming the International Union for Conservation of Nature (IUCN) Center for Mediterranean Cooperation. In this union, the unique Mediterranean climate, or dry summer climate, is characterised by low annual precipitation, mild and wet winter, and hot and dry summer.
Using Petri Nets and 4M1E Identification Resolution for Manufacturing Process Control and Information Tracking: Case Study of Transformer Coil Production
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Interplay of two ${E}_{g}$ orbitals in superconducting ${\mathrm{La}}_{3}{\mathrm{Ni}}_{2}{\mathrm{O}}_{7}$ under pressure
The discovery of high-Tc superconductivity (SC) in La3Ni2O7 (LNO) has aroused a great deal of interest. Previously, it was proposed that the Ni-3dz2 orbital is crucial to realize the high-Tc SC in LNO. The preformed Cooper pairs therein acquire coherence via hybridization with the 3dx2−y2 orbital to form the SC. However, we held a different viewpoint that the interlayer pairing s-wave SC is induced by the 3dx2−y2 orbital, driven by the strong interlayer superexchange interaction.
Highly Efficient Near‐Infrared Luminescent Radicals with Emission Peaks over 750 nm
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Filename Description anie202412483-sup-0001-misc_information.pdf3.6 MB Supporting Information References 1 1a, , , , Acc. Chem. Res.
Enhancing CO2 electroreduction to ethylene via microenvironment regulation in boron-imidazolate frameworks
Enhancing CO2 electroreduction to ethylene via microenvironment regulation in boron-imidazolate frameworks Using the structure-induced effect of KBH(mim)3 ligand, four 2-dimensional (2D) boron imidazolate frameworks with identical body framework and different dangling monocarboxylate ligands, have been synthesized. Electrocatalytic results indicate that the surrounding microenvironment regulation could effectively affect the activity and selectivity towards C2H4.
Bioinspired molecular catalysts with unique tricopper architecture for highly efficient oxygen reduction reaction
Bioinspired molecular catalysts with unique tricopper architecture for highly efficient oxygen reduction reaction In-situ growth of intertwined trinuclear copper complexes (nCu3) on a cellulose-derived carbon support (CMC) produced high-performance electrocatalyst (CMC-nCu3) for the oxygen reduction reaction (ORR), which demonstrated superior performance in zinc-air batteries to commercial Pt/C catalyst.
高原低压低氧环境下牙周炎与中枢神经系统炎症的相关性
摘要: 近年来,随着在高原和山区活动人群的增多,高海拔暴露变得越来越普遍,许多基础疾病患者受高原低压低氧环境影响,病程进一步加重甚至导致认知障碍的现象频发。 牙周炎是一种常见的炎症性疾病,能诱发牙周局部炎症反应,甚至中枢神经系统炎症。 在高海拔环境下,机体出现免疫力下降、组织缺氧等反应,这些反应会促进牙周炎的发生发展,甚至有可能增加牙周炎引发中枢神经系统炎症的风险。 随着高原医学研究的不断深入,高原低压低氧环境下牙周炎与中枢神经系统炎症之间的关系引发越来越多的关注。 本文就牙周炎与中枢神经系统炎症的研究进展进行综述,并对高原低压低氧环境下牙周炎与中枢神经系统炎症之间的相关性进行讨论。
云南鲜食葡萄品质与不同产地土壤养分综合分析及评价
In order to study the soil nutrient status and its impact on grape quality in the main production areas of fresh grapes in Yunnan province，12 sampling points were selected to collect soil samples and corresponding grape samples，relevant indicators were measured and analyzed to provide scientific basis for rational fertilization in Yunnan’s fresh grape production areas.
De fortes pluies causent des inondations dans 22 rivières au Guangxi
De fortes pluies ont causé des inondations dans 22 rivières de la région autonome Zhuang du Guangxi (sud de la Chine), a annoncé dimanche le centre hydrologique régional. Un total de 30 stations hydrologiques dans 22 rivières du Guangxi ont connu des niveaux d'eau de 0,03 mètre à 2,63 mètres au-dessus du seuil d'alerte, a déclaré le centre. La station hydrologique de Hezhou de la rivière Hejiang a signalé la plus grande crue depuis une décennie.
Agriculture | Free Full-Text | Making Decisions on the Development of County-Level Agricultural Industries through Comprehensive Evaluation of Environmental and Economic Benefits of Agricultural Products: A Case Study of Hancheng City
1. Introduction The escalating urgency of addressing global climate change has placed significant emphasis on the need to control and reduce carbon emissions across all sectors. Agriculture, as a substantial source of greenhouse gas emissions, plays a critical role in this effort. It is estimated that agricultural activities contribute approximately 14% of the total global greenhouse gas emissions, highlighting the necessity of implementing effective carbon reduction strategies within this sector.
A Study on the Spatio-Temporal Evolution Characteristics of Social Development Levels in China
1. Introduction In the new era, China’s societal dynamics have undergone a significant transformation. The primary contradiction in Chinese society has shifted from the historical struggle between the people’s growing material needs and scarce resources, to the contradiction between the desire for a better life and unbalanced, inadequate development.
Auditory evoked-potential abnormalities in a mouse model of 22q11.2 Deletion Syndrome and their interactions with hearing impairment
Abstract The 22q11.2 deletion is a risk factor for multiple psychiatric disorders including schizophrenia and also increases vulnerability to middle-ear problems that can cause hearing impairment. Up to 60% of deletion carriers experience hearing impairment and ~30% develop schizophrenia in adulthood. It is not known if these risks interact.
Environmental Regulation and Stormwater Management Strategies for an Urban River in Northwest China: A Sustainable Approach
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Coordination polymer derived Fe-N-C electrocatalyst with high performance for oxygen reduction reaction in Zn-air batteries
Coordination polymer derived Fe-N-C electrocatalyst with high performance for oxygen reduction reaction in Zn-air batteries Developing high performance noble-metal-free electrocatalysts as the alternatives of Pt-based catalysts for the oxygen reduction reaction (ORR) in energy conversion devices is highly desirable.
Highly Efficient Platinum(II) Complexes Overcoming Pt-Pt Interactions and Their Applications in Organic Light-emitting Diodes
Highly Efficient Platinum(II) Complexes Overcoming Pt-Pt Interactions and Their Applications in Organic Light-emitting Diodes Phosphorescent Pt(II) complexes have garnered considerable attention owing to their high photoluminescence quantum efficiencies (PLQEs), tunable emission colors, larger Stokes shifts, and high electrochemical stability.
Investigating the Influencing Factors of the Purchase Intention of the Continuing Care Retirement Community: A Case Study of Shenzhen
1. Introduction Based on the 2020 data from the seventh national population census, China’s population aged 60 and above reached 264 million, comprising 18.7% of the total population, marking a 3-percentage-point increase from 2000. The population over 65 years old amounted to 190 million, representing 13.5% of the total population, with an increase of 5.44 percentage points from 2010.
Achieving Nearly 100% Photoluminescence Quantum Efficiency in Organic Radical Emitters by Fine‐Tuning the Effective Donor‐Acceptor Distance
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202314811-sup-0001-SuppMat.pdf2.2 MB Supporting Information References 1, J. Am. Chem. Soc. 1900, 22, 757. 2a) , Chem. Soc. Rev. 2002, 31, 301; b) , , , , , , , Chem. Phys. Lett. 2000, 330, 110; c) , , , , , J. Phys. Chem. C 2007, 111, 10213. 3, , , , , Science 2018, 359, 1391. 4, , , , , , , , , , , , Angew. Chem., Int. Ed. 2023, 62, e202214281. 5a) , , , , , , , J. Am. Chem. Soc.
Interfacial Engineering of P2-Type Ni/Mn-Based Layered Oxides by a Facile Water-Washing Method for Superior Sodium-Ion Batteries
Download Hi-Res ImageDownload to MS-PowerPointCite This:ACS Appl. Mater. Interfaces 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Applications of Information Technology in Building Carbon Flow
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Molecules | Free Full-Text | A Comprehensive Review of the Pharmacology, Chemistry, Traditional Uses and Quality Control of Star Anise (Illicium verum Hook. F.): An Aromatic Medicinal Plant
1. Introduction Plant-based Chinese medicine is a generic term for Chinese medicines derived from plant resources, which are processed from natural plants or parts of naturally occurring flora under the guidance of the Traditional Chinese Medicine (TCM) doctrine. The medicinal parts of plants for Chinese medicines include roots, rhizomes, stems, leaves, flowers, fruits, seeds, skins and whole herbs [1].
Auditory evoked-potential abnormalities in a mouse model of 22q11.2 Deletion Syndrome and their interactions with hearing impairment
Abstract Background The 22q11.2 chromosomal microdeletion is one of the strongest known genetic risk factors for schizophrenia; ~30% of carriers develop schizophrenia in adulthood. Up to 60% of 22q11.2 deletion carriers also have mild to moderate hearing impairment, primarily from chronic middle-ear inflammation. The Df1/+ mouse model of the 22q11.2 deletion replicates the large inter-individual variation in hearing ability observed among deletion carriers.
Oxidative Stress Contributes to Flumioxazin‐Induced Cardiotoxicity in Zebrafish Embryos
Corresponding Author Huiqiang Lu Ganzhou Key Laboratory for Drug Screening and Discovery, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou, 341000 Jiangxi, China Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Jiangxi Key Laboratory of Developmental Biology of Organs, Clinical Research Center of Affiliated Hospital of Jinggangshan University, College of Life Sciences, Jinggangshan University, Ji'an, 343009...
Screening of the shared pathogenic genes of ulcerative colitis and colorectal cancer by integrated bioinformatics analysis
1 INTRODUCTION Colorectal cancer (CRC) is one of the most prevalent cancers globally, with approximately 1,148,000 new cases and more than 576,000 deaths each year.1 Numerous factors, including environmental and genetic factors, contribute to the aetiology and pathophysiology of CRC.2-4 Furthermore, several high-risk factors, particularly ulcerative colitis (UC), are the leading causes of CRC.5-9 Thus, a thorough investigation of the mechanisms underlying the onset and progression of CRC is...
World Insights: U.S. uses "black sites" to trample on human rights under counterterrorism guise Original
This photo taken on Aug. 4, 2022 shows the White House and a stop sign in Washington, D.C., the United States. (Xinhua/Liu Jie) Throughout the years, the United States has furtively established detention camps in at least 54 countries and regions, using them as interrogation facilities for "terrorist suspects" while attempting to evade jurisdiction and legal challenges.
[경제 인사이트] 중국, 내 보험료 이젠 디지털 위안화로 받는다
[한국미디어뉴스통신=신화통신] 중국 보험업계가 디지털 위안화 도입에 속도를 내고 있다. ◇보험 가입부터 보험금 지급까지...모두 디지털 위안화로 '해결' 보험 업계에서 디지털 위안화 응용은 보험료 납부·청구 등에 이르기까지 그 범위가 점점 더 확대되고 있다. 최근 수년간 비교적 빠르게 성장한 혜민(惠民)보험상품의 경우 허베이(河北)·칭다오(青島)·항저우(杭州) 등 지역에서 이미 디지털 위안화를 사용해 보험에 가입하거나 보험료를 납부하고 있다. 올해 3월엔 '헝친(橫琴)∙웨아오(粵澳, 광둥성-마카오) 심층합작구'에서 최초의 '디지털 위안화 보험 증서'가 발행됐다. 디지털 위안화 지갑을 이용해 생명상해보험 등 보험 상품에 가입할 수 있는 것이 특징이다. 또 자동차 보험 분야에서도 디지털 위안화를 도입한 것으로 나타났다. ▲ 암보험 사망원인 1위! 암보험 저렴하게 확실한 비교 ▲ 치아보험 치아는 오복중에 하나, 1등 치아보험 추천 ▲ 매매잔금 생활자금 사업자금 부족하다면?
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