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Chen-Ying Liu on Muck Rack

Chen-Ying Liu

As seen in: Nature, Frontiers, The Journal of Biological Chemistry
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Articles

Distribution analysis of gynecological carcinomas with concurrent second primary carcinomas

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By Si-Yi Li, Chen-Ying Liu, Xing-Yun Xie, Wen-Juan Chen, Lan-lan Chen
| Frontiers
Abstract Introduction: This study investigates the distribution characteristics, occurrence time and clinicopathological correlations of second primary carcinoma (SPC) in patients with cervical carcinoma (CC) and endometrial carcinoma (EC) to guide precise monitoring. Materials and methods: This retrospective study analyzed 253 CC patients and 102 EC patients diagnosed with SPC at Fujian Cancer Hospital between April 2014 and April 2024.
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AMBRA1 promotes intestinal inflammation by antagonizing PP4R1/PP4c mediated IKK dephosphorylation in an autophagy-independent manner - Cell Death & Differentiation

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By Long Cui, Yingwei Chen, Chen-Ying Liu, Yubei Gu
| Nature Verified
Abstract IκB kinase (IKK) complex is central regulators of the NF-κB pathway, and dysregulation of IKK phosphorylation leads to hyperactivation of proinflammatory response in various chronic inflammatory diseases, including inflammatory bowel disease (IBD). However, the dynamic modulation of IKK phosphorylation and dephosphorylation in intestinal inflammation remains uncharacterized.
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Rational design of a sensitivity-enhanced tracer for discovering efficient APC–Asef inhibitors - Nature Communications

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By Shaoyong Lu, Jianfeng Cai, Guoqiang Chen, Chen-Ying Liu, Jian Zhang
| Nature Verified
Abstract The adenomatous polyposis coli (APC)–Rho guanine nucleotide exchange factor 4 (Asef) protein–protein interaction (PPI) is essential for colorectal cancer metastasis, making it a promising drug target. Herein, we obtain a sensitivity-enhanced tracer (tracer 7) with a high binding affinity (Kd = 0.078 μM) and wide signal dynamic range (span = 251 mp).
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