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Articles by Chenchen He
Architecting bioinspired nanocrystalline domains for ultimate robust and transparent cellulose photonic hydrogels
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Biomimetic spider silk achieves remarkable functionalities through hierarchical architectures with highly oriented crystalline domains, offering potential across multiple disciplines.
Architecting bioinspired nanocrystalline domains for ultimate robust and transparent cellulose photonic hydrogels
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Biomimetic spider silk achieves remarkable functionalities through hierarchical architectures with highly oriented crystalline domains, offering potential across multiple disciplines.
CXCR5 + monocyte emigration impairs the radiation-induced antitumor immune response
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Abstract A substantial portion of patients experience radioresistance, which impedes clinical benefit. The radiation-induced ‘protumor’ immune response is previously demonstrated to limit antitumor efficacy. However, the detailed mechanism remains to be explored. In this study, we observe CXCR5+ monocytes are enriched in tumor upon radiation. CXCR5 expression on monocytes in host is induced by tumor-derived VEGF through PI3K/mTOR/HIF-1α axis.
By Rui Jia, Chen Chen, Jiahong Shi, Mengdi Huang, Yixin Wang, Jiahao Sun, Yihan Wang, Tingting Lv, Ruiying Wang, Junyi Zhang, Du Yang, Hanmin Tang, Jianan Li, Liuyi Yang, Renyi Ding, Wenhua Li, Haiyan Liu, Anjun Jiao, Lingyun Hui, Shan Huang, Mengjiao Cai, Chenchen He, Chen Lin Verified, Fei Wang, Jinlu Ma, Suxia Han, Yuzhu Hou, Yutiantian Lei, Peihai Cao, Qiuyu Mu, Dairu Hou, Mingjun Si, Ruishan Guo, Dingge Jiang, Yanxia Sui
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Nature
Verified
CD131 contributes to ulcerative colitis pathogenesis by promoting macrophage infiltration
eLife Assessment Ulcerative colitis (UC) is a chronic gut inflammatory condition affecting the colon in humans. This study uses human samples as well as a mouse model of colitis induced by a chemical, DSS, to investigate the role of an immune marker, CD131, in UC pathogenesis. The study, as presented, is incomplete, as experimental details are lacking, the statistical analyses are deficient, and there is not yet direct evidence for a CD131-mediated mechanism of gut inflammation.
Risk Factors for Sinusoidal Obstruction Syndrome After Hematopoietic Stem Cell Transplantation in Children and Young Adults: A Systematic Review and Meta‐Analysis
• , , , et al., “ Diagnosis and Severity Criteria for Sinusoidal Obstruction Syndrome/Veno-Occlusive Disease in Pediatric Patients: A New Classification From the European Society for Blood and Marrow Transplantation ,” Bone Marrow Transplantation , no. ( ): – . • , , , and , “ Hepatic Venoocclusive Disease in Blood and Bone Marrow Transplantation in Children and Young Adults: Incidence, Risk Factors, and Outcome in a Cohort of 241 Patients ,” Journal of Pediatric Hematology/Oncology , no. ( ): – .
Challenges for breast radiotherapy with SIB: the IMPORT HIGH trial
Charlotte E Coles and colleagues 1 Coles CE Haviland JS Kirby AM et al. Dose-escalated simultaneous integrated boost radiotherapy in early breast cancer (IMPORT HIGH): a multicentre, phase 3, non-inferiority, open-label, randomised controlled trial. discuss the latest results from the IMPORT HIGH research, a phase 3 randomised trial that assessed three hypofractionated radiation treatments for efficacy and safety.
The Deacylase Sirtuin 5 Reduces Malonylation in Non-mitochondrial Metabolic Pathways in Diabetic Kidney Disease
Experimental Procedures Materials 13C6 glucose was purchased from Cambridge Isotope Labs Inc. Human kidney 2 (HK2) cells were purchased from American Type Culture Collection (ATCC® CRL-2190™). LC–MS-grade water, acetonitrile (ACN), chloroform and methanol were obtained from Fisher Scientific. Malonyl-CoA and 13C3-malonyl-CoA standards were purchased from Sigma Aldrich. All other chemicals used in the study were purchased from Sigma Aldrich unless otherwise indicated.
Lipidomic approaches to dissect dysregulated lipid metabolism in kidney disease - Nature Reviews Nephrology
Authors and Affiliations Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA Judy Baek & Subramaniam Pennathur Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA Chenchen He, Farsad Afshinnia & Subramaniam Pennathur Department of Statistics, University of Florida, Gainesville, FL, USA George Michailidis Contributions J.B. wrote the first draft of the article.
Circulating Free Fatty Acid and Phospholipid Signature Predicts Early Rapid Kidney Function Decline in Patients With Type 1 Diabetes
Pathophysiology/Complications Abstract OBJECTIVES Patients with type 1 diabetes (T1D) exhibit modest lipid abnormalities as measured by traditional metrics. This study aimed to identify lipidomic predictors of rapid decline of kidney function in T1D. RESEARCH DESIGN AND METHODS In a case-control study, 817 patients with T1D from three large cohorts were randomly split into training and validation subsets.
Circulating Free Fatty Acid and Phospholipid Signature Predicts Early Rapid Kidney Function Decline in Patients With Type 1 Diabetes
Pathophysiology/Complications Circulating Free Fatty Acid and Phospholipid Signature Predicts Early Rapid Kidney Function Decline in Patients With Type 1 Diabetes Farsad Afshinnia, Thekkelnaycke M. Rajendiran, Chenchen He, Jaeman Byun, Daniel Montemayor, Manjula Darshi, Jana Tumova, Jiwan Kim, Christine P. Limonte, Rachel G. Miller, Tina Costacou, Trevor J. Orchard, Tarunveer S. Ahluwalia, Peter Rossing, Janet K. Snell-Bergeon, Ian H.
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