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Articles by Chenchen Hu
Efficacy of methimazole combined with traditional Chinese medicine in the treatment of Graves’ disease: a systematic review and network meta-analysis
Abstract Introduction: Traditional Chinese Medicine (TCM) Combined with Methimazole (MMI) versus MMI Alone for Thyroid Function and Autoantibodies in Graves’ Disease(GD). Methods: A systematic literature search was performed in PubMed, Cochrane Library, Web of Science, EMBASE, CNKI, VIP, CBM, and Wanfang databases up to June 2025 for RCTs comparing TCM plus MMI versus MMI alone. Study risk of bias was evaluated using the Cochrane tool.
Exploring the potential mechanism of artemisinin against gastric cancer based on network pharmacology, machine learning and experimental validation
Abstract Background: Artemisinin, a natural active component extracted from Artemisia annua, exhibits potential anti-gastric cancer activity; however, its specific targets and molecular mechanisms remain unclear. Methods: Network pharmacology was used to predict the potential targets of artemisinin. Differential expression analysis and weighted gene co-expression network analysis (WGCNA) were performed to identify gastric cancer-related genes.
An activated wheat CC G10 -NLR immune receptor forms an octameric resistosome
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Keywords CCG10-NLRs cryo-EM octameric resistosome cytosolic calcium elevation EDVID motif divergent CC domain configuration wheat autoimmunity Introduction Nucleotide-binding, leucine-rich repeat (NLR) proteins function as key immune receptors across diverse taxa.1 These intracellular proteins detect pathogen invasion and activate defense responses.2 The NLR family is defined by its characteristic tripartite architecture: an N-terminal signaling domain that executes downstream immune...
By Guanghao Guo, He Zhao, Kaihong Bai, Jian Lu, Qiuhong Wu, Lei Lu, Yue Zhang, Lingli Dong, Guangwei Li, Yongxing Chen, Yikun Hou, Ping Lu, Miaomiao Li, Huaizhi Zhang, Gaojie Wang, Keyu Zhu, Baoge Huang, Xuejia Cui, Hongkui Fu, Chenchen Hu, Zhiying Chu, Xue Lyu, Sophien Kamoun, Chao Wang, zhiyong Liu, Muniyandi Selvaraj, Jonathan Jones
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tubular concrete ring by HCCH studio shapes cycling rest pavilion among chinese hills
concrete ring pavilion forms a cycling rest stop in Mount Luofu Resting Loop with Views is a small pavilion project by HCCH Studio located on a stone platform within the mountainous landscape of Mount Luofu, China. Positioned between a highway and a parallel river, the site previously functioned as a buffer zone and informal parking area at a sharp roadway curve.
translucent illuminating dome bears bronze lattice of flower motifs in shanghai
HCCH Studio weaves osmanthus motifs into translucent dome Osmanthus Moon is a temporary public art installation by HCCH Studio, created to mark the traditional Chinese Mid-Autumn Festival. The project references the osmanthus flower, an emblematic plant associated with the season, and establishes a dialogue with the action paintings of a folk Zao Hua (stove flower) artist, a practice recognized as an element of intangible cultural heritage.
TLR7: A Key Prognostic Biomarker and Immunotherapeutic Target in Lung Adenocarcinoma
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Metabolic Reprogramming of Immune Cells in the Tumor Microenvironment
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
three ecological pavilions by HCCH studio craft unconventional follies on shanghai's coast
HCCH Studio’s Ecological Pavilions utilize Sustainable Materiality Lingang Coast Ecological Pavilions, part of the Shanghai Lingang Ecological Restoration Project, dot the 17-kilometer coastline, serving as landmarks and educational hubs for citizens. Designed by HCCH Studio, each of the three pavilions boasts unique characteristics, offering a blend of architectural intrigue and environmental consciousness.
three ecological pavilions by HCCH studio craft unconventional follies on shanghai’s coast
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Improvement of Lung Function by Micronutrient Supplementation in Patients with COPD: A Systematic Review and Meta-Analysis
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
HCCH studio stacks hundreds of red bricks to craft spiral shell library in china
Twisted Brick Shell Concept Library by HCCH Studio In the rural landscape of Zhejiang Province, China, HCCH Studio has designed a brick spiral shell to serve as a concept library for the local community. Nestled within a high grass field, the structure measures approximately 10 meters in diameter and stands 5 meters high. The primary goal of the project was to explore the integration of contemporary formal expression with vernacular material culture.
HCCH studio stacks hundreds of red bricks for spiral shell library in china
through this structure, the team seeks to explore the integration of contemporary formal expression with vernacular material culture. The post HCCH studio stacks hundreds of red bricks for spiral shell library in china appeared first on designboom | architecture & design magazine.
dragon-like spiral installation by HCCH studio infuses sci-fi aesthetics into shanghai district
HCCH studio installs interwoven double-helix piece in shanghai A vibrant spiraling installation by HCCH Studio welcomes passersby to the entrance of the newly constructed Shikumen-style commercial district in Shanghai. Comprised of 1,300 elliptical illuminated rings and colorful bands, the public artwork bears a resemblance to a dragon-shaped creature celebrating the Lunar New Year.
sea monitoring stations twist and swirl along shanghai's coastline
HCCH STUDIO develops TWISTING TOWER AND SPIRAL STATION Twisting Tower and Spiral Station by HCCH Studio stand as integral structures within the Shanghai Lingang Ecological Restoration Project, positioned 10 kilometers apart along the coastline. These constructions aim to redefine the role of infrastructure, serving ecological purposes while subtly engaging the public in environmental discourse through understated design.
sea monitoring stations twist and swirl along shanghai’s coastline
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Genome-Wide Association Study on Seedling Phenotypic Traits of Wheat under Different Nitrogen Conditions
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Calculation Method of the Design Thickness of a Frozen Wall with Its Inner Edge Radially Incompletely Unloaded
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Near-Infrared Triggered Self-Accelerating Nanozyme Camouflaged with a Cancer Cell Membrane for Precise Targeted Imaging and Enhanced Cancer Immunotherapy
Download Hi-Res ImageDownload to MS-PowerPointCite This:Anal. Chem. 2023, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
An Efficient Biomimetic Nano-Regulator Inducing Simultaneous Calcium Ion/Nitric Oxide/Energy Metabolism Triple Homeostasis Disruption for Synergetic Cancer Therapy
An Efficient Biomimetic Nano-Regulator Inducing Simultaneous Calcium Ion/Nitric Oxide/Energy Metabolism Triple Homeostasis Disruption for Synergetic Cancer Therapy Chenchen Hu, Fan Jiang, Yixiao Li, Ruiyang Man and Zhengze Yu Abstract Inducing homeostasis disruption in cancer cells will cause severe cytotoxicity and apoptosis for cancer therapy. However, comprehensive intracellular active homeostatic mechanisms make it still a daunting challenge.
miR‐145 inhibits aerobic glycolysis and cell proliferation of cervical cancer by acting on MYC
2 MATERIALS AND METHODS Cell cultures In this study, the human CC cell lines HeLa and SiHa were purchased from GeneChem Co., Ltd. (Shanghai, China). Both cell lines were authenticated by STR profiling and routinely tested for mycoplasma contamination. Cells were cultured according to Ref. [10]. Plasmid and siRNA transfection MiR-145 mimics are chemically synthesized small double-stranded miRNAs, which mimic endogenous miRNAs by up-regulating the content of corresponding miRNAs in cells.
[METTL14 promotes the proliferation and migration of cervical cancer cells by up-regulating mA Myc expression].
Objective To investigate the effect of methyltransferase-like 14 (METTL14) on the proliferation and metastasis of cervical cancer cells and its possible molecular mechanism. Methods The expression of METTL14 and Myc in cervical cancer tissues and normal tissues were analyzed using Gene Expression Omnibus (GEO) database and cervical cancer tissue microarray. The expression of METTL14 in HeLa and SiHa cells was silenced by small interfering RNA.
Carbon Nanotube-Modified Nickel Hydroxide as Cathode Materials for High-Performance Li-S Batteries
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited.
Dont Starve Guide
Date: 2021-01-12 Category: Entertainment OS: iOS Compatible: iPhone iPad Requirements: Requires iOS 13.0 or complete guide starve starve guide dont starve dont starve guide Description - Dont Starve Guide . The Dont Starve Guide is now available as a free download on Apple Store for both iPhone and iPad owners.The application is available in multiple languages: English, Simplified Chinese, Traditional Chinese. It weighs in at only 24.5 MB to download.
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