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Sophien Kamoun on Muck Rack

Sophien Kamoun

Norwich
As seen in: Medium, Nature, PLOS Biology, Genome Biology, Science Magazine, BioRxiv, Cell Press, Agroempresario
Biologist at The Sainsbury Lab; passionate about plant pathogens and evolution; open science advocate; loves travel, food and sports; nomad and hunter-gatherer.
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Articles

A potato late blight pathogen effector interacts with ENTH-domain protein TOL9a and an activated helper NLR to suppress immunity

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By Youngmin Ko, John Hintze, Luise Fast, Jogi Madhuprakash, AmirAli Toghani, Hsuan Pai, Madia Harvey, Adam R. Bentham, Benjamin A Seager, Juan Carlos de la Concepcion, David Lawson, Clare E. M. Stevenson, Angel Vergara-Cruces, Lida Derevnina, Tolga Bozkurt, Mark Banfield, Sophien Kamoun, Mauricio P. Contreras
| Science Magazine Verified
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Pathogens counteract central nodes of NLR immune receptor networks to suppress immunity. However, the mechanisms by which pathogens hijack helper NLR pathways are poorly understood.
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A plant pathogen effector blocks stepwise assembly of a helper NLR resistosome

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By Youngmin Ko, John Hintze, Luise Fast, Benjamin A Seager, Adeline Harant, Mauricio P. Contreras, Liang-Yu Hou, Chih Hang Wu, Sophien Kamoun, Jogi Madhuprakash
| Science Magazine Verified
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Helper NLRs function as central nodes in plant immune networks. Upon activation, they oligomerize into inflammasome-like resistosomes to initiate immune signaling, yet the dynamics of resistosome assembly remain poorly understood.
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An activated wheat CC G10 -NLR immune receptor forms an octameric resistosome

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By Guanghao Guo, He Zhao, Kaihong Bai, Jian Lu, Qiuhong Wu, Lei Lu, Yue Zhang, Lingli Dong, Guangwei Li, Yongxing Chen, Yikun Hou, Ping Lu, Miaomiao Li, Huaizhi Zhang, Gaojie Wang, Keyu Zhu, Baoge Huang, Xuejia Cui, Hongkui Fu, Chenchen Hu, Zhiying Chu, Xue Lyu, Sophien Kamoun, Chao Wang, zhiyong Liu, Muniyandi Selvaraj, Jonathan Jones
| Cell Press Verified
Keywords CCG10-NLRs cryo-EM octameric resistosome cytosolic calcium elevation EDVID motif divergent CC domain configuration wheat autoimmunity Introduction Nucleotide-binding, leucine-rich repeat (NLR) proteins function as key immune receptors across diverse taxa.1 These intracellular proteins detect pathogen invasion and activate defense responses.2 The NLR family is defined by its characteristic tripartite architecture: an N-terminal signaling domain that executes downstream immune...
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