Chengjie Lian on Muck Rack

Chengjie Lian

As seen in: The Journal of Clinical Investigation
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Articles

Notch1 O-GlcNAcylation drives tumor stemness and mechanoadaptation to a stiff microenvironment and promotes chordoma recurrence

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By Chengjie Lian, Weiyan Peng, Peiqiang Su
| The Journal of Clinical Investigation
Abstract Chordomas are rare malignant osseous neoplasms with a striking rate of recurrence. Primary chordomas typically originate from embryonic notochord remnants, whereas recurrent chordomas usually stem from tumor cells infiltrating bone or cartilage after surgery. Clinically, the recurrent chordomas exhibit a stiffer extracellular microenvironment (ECM) than primary tumors.
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