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Chengliang Yin on Muck Rack

Chengliang Yin

As seen in: Nature, Wiley Online Library, Frontiers, Royal Society of Chemistry, Cell Reports Medicine, Canadian Journal of Infectious Diseases & Medical Microbiology
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Articles

Targeting m6A-SCG2-TAMs axis overcomes 5-FU resistance in colorectal cancer via a multi-omics model

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By Yiming Sun, Ke Peng, Yuening Li, Ling Liu, Jiuheng Yin, Kun Yu, Cong Xu, Joao Pedro Conde, João Rafael Conde, Zhixi Li, Chengliang Yin, Wensheng Wang, Weidong Xiao, Daofeng Zheng
| Nature Verified
Abstract Chemoresistance to 5-fluorouracil (5-FU) remains a critical barrier in colorectal cancer (CRC) management. This study integrates multi-omics data from 26,192 human samples to elucidate the RNA methylation-mediated crosstalk between tumor-associated macrophages (TAMs) and tumor cells.
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Clinical large language model centered on electronic medical records

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By Yan Zhuang Verified, Bo Wang, Chengliang Yin, Junyan Zhang, Fanqing Meng, Jianfei Zhao, Qingyong Su, Xuan Zhao, Ping Ping Hu, Shiyuan Liu, Rilige Wu, Yun Hua, Wei Dong, Bing Wei, Li Zhang, Lei Zheng, Joao Pedro Conde, João Rafael Conde, Ge Shi, Chong Feng, Kunlun He, Xiuxing Li
| Nature Verified
Abstract In the quest to enhance medical consultation, our study introduces AI4Doctor, a sophisticated large-language model (LLM) tailored for the clinical domain. At the heart of AI4Doctor is an innovative integration strategy that synergizes distilled data extracted from electronic medical records (EMR) with empirical insights gathered from practicing physicians during the supervised fine-tuning.
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Materials-Guided Gene-Ionizable Lipid Nanoparticles to Reverse Iron-Associated Immune Resistance in Renal Cancer

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By Xin Jin, Yulong Hong, Chengliang Yin
| Wiley Online Library Verified
1 Introduction Cancer is recognized as a systemic and holistic disease, with changes in various nutrients and metabolites in the body affecting cancer progression in diverse ways [1]. Iron is an essential trace element in the human body, yet iron disorders affect billions of patients worldwide, including cancer patients [2]. Early large-scale population studies showed that individuals with moderately elevated iron levels have an increased risk of cancer [3, 4].
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