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Articles by Chengpeng Chen
3D‐Printed Microfluidic‐Based Cell Culture System With Analysis to Investigate Macrophage Activation
Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description elps8109-sup-0001-SuppMat.pdf1.3 MB Supporting Information References 1, , and , “Review of 3D Cell Culture with Analysis in Microfluidic Systems,” Analytical Methods 11 (2019): 4220–4232. 2, , , and , “Paper-Based Cell Culture Microfluidic System,” BioChip Journal 9 (2015): 97–104.
Recent Advances in Wearable Sweat Sensor Development
Conflicts of Interest The authors declare no conflicts of interest. References , , , and . 2022. “Materials for Wearable Sensors.” Materials Innovations 2: 188–193. , , , et al. 2019. “A Multichannel Electrochemical All-Solid-State Wearable Potentiometric Sensor for Real-Time Sweat Ion Monitoring.” Electrochemistry Communications 107: 106553. , , , et al. 2017. “A Wearable Multisensing Patch for Continuous Sweat Monitoring.” Biosensors and Bioelectronics 93: 139–145. , and . 2020.
Organs-on-chips: Tech that can help researchers conduct studies closer to real-life conditions
By Chengpeng Chen—The Conversation January 27, 2023 Bringing a new drug to market costs billions of dollars and can take over a decade. These high monetary and time investments are both strong contributors to today’s skyrocketing healthcare costs and significant obstacles to delivering new therapies to patients. One big reason behind these barriers is the lab models researchers use to develop drugs in the first place.
Organs-on-chips: Tech that can help researchers conduct studies closer to real-life conditions
Bringing a new drug to market costs billions of dollars and can take over a decade. These high monetary and time investments are both strong contributors to today’s skyrocketing healthcare costs and significant obstacles to delivering new therapies to patients. One big reason behind these barriers is the lab models researchers use to develop drugs in the first place.
Reconstituer des " organes sur puce ", une voie vers de nouveaux médicaments ?
Les essais précliniques, c’est-à-dire les études qui permettent de tester l’efficacité et la toxicité d’un médicament avant qu’il ne fasse l’objet d’essais cliniques chez l’homme, sont principalement réalisés sur des cultures cellulaires et des animaux. Ces deux méthodes sont limitées par leur faible capacité à reproduire les conditions du corps humain.
Organs-on-chips: Tech that can help researchers conduct studies closer to real-life conditions
By Chengpeng Chen—The Conversation 4 minute Read Bringing a new drug to market costs billions of dollars and can take over a decade. These high monetary and time investments are both strong contributors to today’s skyrocketing healthcare costs and significant obstacles to delivering new therapies to patients. One big reason behind these barriers is the lab models researchers use to develop drugs in the first place.
Reconstituer des " organes sur puce ", une voie vers de nouveaux médicaments ?
La mise sur le marché d'un nouveau médicament coûte des milliards d'euros et peut prendre plus de dix ans. Ces investissements considérables en argent et en temps contribuent fortement à la montée en flèche des coûts de santé et constituent des obstacles importants à la mise à disposition de nouvelles thérapies pour les patients. L'un des obstacles réside dans les modèles de laboratoire utilisés par les scientifiques pour développer les médicaments.
3D-printed “organs” could lead to better drugs
Bringing a new drug to market costs billions of dollars and can take over a decade. These high monetary and time investments are both strong contributors to today’s skyrocketing health care costs and significant obstacles to delivering new therapies to patients. One big reason behind these barriers is the lab models researchers use to develop drugs in the first place.
Can organs-on-a-chip replace animals in medical experiments?
Bringing a new drug to market costs billions of dollars and can take over a decade. These high monetary and time investments are both strong contributors to today’s skyrocketing health care costs and significant obstacles to delivering new therapies to patients. One big reason behind these barriers is the lab models researchers use to develop drugs in the first place.
Organ-on-a-chip models allow researchers to conduct studies closer to real-life conditions
Bringing a new drug to market costs billions of dollars and can take over a decade. These high monetary and time investments are both strong contributors to today's skyrocketing health care costs and significant obstacles to delivering new therapies to patients. One big reason behind these barriers is the lab models researchers use to develop drugs in the first place.
Organ-on-a-chip models allow researchers to conduct studies closer to real-life conditions -and possibly grease the drug development pipeline
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Organ-on-a-chip models allow researchers to conduct studies closer to real-life conditions - and possibly grease the drug development pipeline
Bringing a new drug to market costs billions of dollars and can take over a decade. These high monetary and time investments are both strong contributors to today’s skyrocketing health care costs and significant obstacles to delivering new therapies to patients. One big reason behind these barriers is the lab models researchers use to develop drugs in the first place.
EMERGING 3D PRINTING TECHNOLOGIES AND METHODOLOGIES FOR MICROFLUIDIC DEVELOPMENT
EMERGING 3D PRINTING TECHNOLOGIES AND METHODOLOGIES FOR MICROFLUIDIC DEVELOPMENT Giraso Keza Monia Kabandana, Tao Zhang and Chengpeng Chen Abstract This review paper examines recent (mostly 2018 or later) advancements in 3D printed microfluidics. Microfluidic devices are widely applied in various fields such as drug delivery, point-of-care diagnosis, and bioanalytical research. In addition to soft lithography, recently, 3D printing has become an appealing technology for developing microfluidics.
From Cells-on-a-chip to Organs-on-a-chip: Scaffolding Materials for 3D Cell Culture in Microfluidics
From Cells-on-a-chip to Organs-on-a-chip: Scaffolding Materials for 3D Cell Culture in Microfluidics Here we present a review paper of 181 references, which analyzes the emerging research area of integrating scaffolding materials in microfluidic devices for 3D cell culture (organs-on-a-chip). The technology of organs-on-a-chip holds the potential to obviate the gaps between pre-clinical and clinical studies.
Organ-on-a-chip models allow researchers to conduct studies closer to real-life conditions - and possibly grease the drug development pipeline
Wyss Institute for Biologically Inspired Engineering, Harvard University/Flickr Bringing a new drug to market costs billions of dollars and can take over a decade. These high monetary and time investments are both strong contributors to today’s skyrocketing health care costs and significant obstacles to delivering new therapies to patients. One big reason behind these barriers is the lab models researchers use to develop drugs in the first place.
Use of 3D printing and modular microfluidics to integrate cell culture, injections and electrochemical analysis
Fabrication of microchip-based devices using 3D printing technology offers a unique platform to create separate modules that can be put together when desired for analysis. A 3D printed module approach offers various advantages such as file sharing and the ability to easily replace, customize, and modify the individual modules. Here, we describe the use of a modular approach to electrochemically detect the ATP-mediated release of nitric oxide (NO) from endothelial cells.
Microchip-based 3D-cell culture using polymer nanofibers generated by solution blow spinning
Polymer nano/micro fibers have found many applications including 3D cell culture and the creation of wound dressings. The fibers can be produced by a variety of techniques that include electrospinning, the primary disadvantage of which include the requirement for a high voltage supply (which may cause issues such as polymer denaturation) and lack of portability.
A Quantitative, In Vitro Appraisal of Experimental Low-Glucose Storage Solutions used for Blood Banking
Red Blood Cell (RBC) transfusion has become one of the most widely utilized life-saving activities in hospitals. The most recent national report on blood banking indicates a decline in blood shortages and infections.
3D-printed microfluidic devices: fabrication, advantages and limitations-a mini review
A mini-review with 79 references. In this review, the most recent trends in 3D-printed microfluidic devices are discussed. In addition, a focus is given to the fabrication aspects of these devices, with the ESI containing detailed instructions for designing a variety of structures including: a microfluidic channel, threads to accommodate commercial fluidic fittings, a flow splitter; a well plate, a mold for PDMS channel casting; and how to combine multiple designs into a single device.
Use of electrospinning and dynamic air focusing to create three-dimensional cell culture scaffolds in microfluidic devices
Organs-on-a-chip has emerged as a powerful tool for pharmacological and physiological studies. A key part in the construction of such a model is the ability to pattern or culture cells in a biomimetic fashion. Most of the reported cells-on-a-chip models integrate cells on a flat surface, which does not accurately represent the extracellular matrix that they experience in vivo.
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