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Chengshun Chen on Muck Rack

Chengshun Chen

As seen in: Nature, Arthritis Research & Therapy
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Articles

IRAK2 deficiency causes immune dysregulation through defective Myddosome assembly and enhanced interferon responses

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By Yudie Fei, Lin Liu, Shuangyue Ma, Ying Jin, Shihao Wang, Liang Zhang, Jun Yang, Yi Liu, Meiping Lu, Jing XUE, Jingyi Li, Xiang Chen, Jun Wang, Yuhao Yao, Chenlu Liu, Jiahui Zhang, Xu Han, Jinjian Fu, Zhijuan Kang, Yusha Wang, Xiangwei Sun, Changming Zhang, Tingyan He, Zhihui Liu, Li Guo, Chengshun Chen, Hongmei Zhao, Xingjian Gao, Hua Zhong, Lihong Wen, Xiaomin Yu, Zhihong Liu, Qing Zhou
| Nature Verified
Abstract Interleukin-1 receptor-associated kinase 2 (IRAK2) is essential for the Myddosome complex formation downstream of Toll-like receptors. We identify twelve patients with a homozygous loss-of-function copy number variant in IRAK2, designated IRAK2-∆ex2. Most patients present with recurrent infections, autoantibody production, and gastrointestinal ulceration.
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