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Chenshuo Yin

As seen in: BioRxiv, Cell Press
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Articles

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis

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By Soichiro Asami, Chenshuo Yin, Jean Fan, Luis Garza, Reza Kalhor
| Cell Press Verified
Keywords deep-tissue spatial transcriptomics developmental instability hair follicle organogenesis developmental delay birth defect nude mouse Foxn1 deficiency 4D mapping spatial pseudotiming developmental dynamics Introduction Organ formation is a dynamic process involving the orderly emergence of new cell types and their coordinated growth and assembly into three-dimensional (3D) structures with specialized functions.
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Deconvolving organogenesis in space and time via spatial transcriptomics in thick tissues

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By Soichiro Asami, Luis Garza, Reza Kalhor, Chenshuo Yin
| BioRxiv
Abstract Organ development is guided by a space-time landscape that constraints cell behavior. This landscape is challenging to characterize for the hair follicle — the most abundant mini organ — due to its complex microscopic structure and asynchronous development. We developed 3DEEP, a tissue clearing and spatial transcriptomic strategy for characterizing tissue blocks up to 400 μm in thickness.
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