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Branched chain fatty acid-rich diet promotes lipid droplet enlargement and impacts organismal health in Caenorhabditis elegans
Abstract Considerable amounts of branched chain fatty acids (BCFAs) are present in the human diet from beef and dairy products. BCFAs can also be produced by the human gut microbiota and synthesized from branched chain amino acids. However, the physiological impact of a BCFA-rich diet on lipid metabolism and organismal health is unclear.
Trichostatin C Synergistically Interacts with DNMT Inhibitor to Induce Antineoplastic Effect via Inhibition of Axl in Bladder and Lung Cancer Cells
1. Introduction Hyperactivation of histone deacetylase (HDAC; EC 3.5.1.98) has been correlated with initiation and progression in a number of malignancies []. HDACs are a group of enzymes used to remove acetyl groups from the lysine residues of histone to maintain a compacted chromatin structure, which leads to transcriptional repression and silencing of tumor suppressor genes [].
Metabolic rescue of α-synuclein-induced neurodegeneration through propionate supplementation and intestine-neuron signaling in C. elegans
Highlights • Depleting dietary VB12 or supplementing propionate suppresses neurodegeneration • Neuronal proteotoxicity triggers mitoUPR and metabolic rewiring in the intestine • Propionate supplementation reverses PD-associated transcriptomic aberration • Increased propionate rescues intestinal energy failure and enhances neuronal health Summary Microbial metabolites that can modulate neurodegeneration are promising therapeutic targets.
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