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Lactate Elicits ER-Mitochondrial Mg2+ Dynamics to Integrate Cellular Metabolism

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By Cassidy C. Daw, Karthik Ramachandran, Benjamin T. Enslow, Soumya Maity, Weiwei Wang, Travis R. Madaris, Christopher Shannon, Brian Bursic, Matthew J. Novello, Cherubina S. Rubannelsonkumar, Joel Ravichandran, Terry M. Bakewell
| ScienceDirect Verified
Highlights • L-lactate triggers ER Mg2+ release that promotes mitochondrial Mg2+ uptake • Mg2+ is a second messenger for metabolic circuits • Limiting Mrs2-mediated Mg2+ uptake enhances mitochondrial bioenergetics • Inflammation-induced lactate contributes to organ failure via mMg2+ surge Summary Mg2+ is the most abundant divalent cation in metazoans and an essential cofactor for ATP, nucleic acids, and countless metabolic enzymes.
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