Chi Ho Chan on Muck Rack

Chi Ho Chan

As seen in: American Society for Microbiology (ASM)
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Articles

AptaGPT: Advancing aptamer design with a generative pre-trained language model

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By Shijian Ding, Xin Yang, Chi Ho Chan, Yuan Ma
| biorxiv.org
Abstract Aptamers, synthetic oligonucleotide ligands, have shown significant promise for therapeutic and diagnostic applications owing to their high specificity and affinity for target molecules. However, the conventional Systematic Evolution of Ligands by Exponential Enrichment (SELEX) for aptamer selection is time-consuming and often yields limited candidates.
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Identification of Different Putative Outer Membrane Electron Conduits Necessary for Fe(III) Citrate, Fe(III) Oxide, Mn(IV) Oxide, or Electrode Reduction by Geobacter sulfurreducens

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By Fernanda Jiménez Otero, Daniel Bond, Chi Ho Chan
| American Society for Microbiology (ASM)
ABSTRACTAt least five gene clusters in the Geobacter sulfurreducens genome encode putative “electron conduits” implicated in electron transfer across the outer membrane, each containing a periplasmic multiheme c-type cytochrome, integral outer membrane anchor, and outer membrane redox lipoprotein(s).
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