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Repurposing pitavastatin and atorvastatin to overcome chemoresistance of metastatic colorectal cancer under high glucose conditions - Cancer Cell International
The DepMap portal (https://depmap.org/portal/) [24] serves as a comprehensive repository for multiomics databases since it incorporates datasets from the Profiling Relative Inhibition Simultaneously in Mixtures (PRISM) and Cancer Cell Line Encyclopedia (CCLE) databases. The PRISM database contains drug sensitivity screening data for 4,686 compounds found in 750 cells.
Engineered extracellular vesicles carrying let-7a-5p for alleviating inflammation in acute lung injury - Journal of Biomedical Science
Bionet Therapeutics, Taiwan, kindly provided WJ-MSCs for EV production and all subsequent in vitro and in vivo experiments. Cell analysis through flow cytometry was conducted to confirm the presence of specific markers (for MSCs: CD105+, CD44+, CD29+, CD90+, CD73+, CD13+, CD45−, CD14−, CD34−, CD31−, CD19−, and HLA-DR−) before their use.
Repurposing thioridazine for inducing immunogenic cell death in colorectal cancer via eIF2α/ATF4/CHOP and secretory autophagy pathways
Cell Communication and Signaling, Jul 2023 Colorectal cancer (CRC) is a highly prevalent cancer type with limited targeted therapies available and 5-year survival rate, particularly for late-stage patients. There have been numerous attempts to repurpose drugs to tackle this problem. It has been reported that autophagy inducers could augment the effect of certain chemotherapeutic agents by enhancing immunogenic cell death (ICD).
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