Chianna Dane on Muck Rack

Chianna Dane

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Articles

Desulfonylative halogenation of arene sulfonyl chlorides using N-halosuccinimides: Synthesis, molecular docking, and anti-Alzheimer activity

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By Michael Kassiou, Luca Pozzetti, Chianna Dane, Christopher R.M. Asquith
| ScienceDirect Verified
Considering the significant biological potential of halogenated arenes, we developed a novel and eco-friendly method for accessing dihalogenated arenes via N-halosuccinimide-promoted desulfonylative halogenation of arenesulfonyl chlorides under metal-free conditions. In silico evaluations of selected compounds for amyloid-beta (Aβ) protein interactions identified compounds 1d and 2d as promising candidates, exhibiting strong binding potential and low toxicity in wild-type Oregon R flies.
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