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Chiara Bardella

As seen in: Nature, MDPI, Cell Press
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Articles

Mutant IDH in Gliomas: Role in Cancer and Treatment Options

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By Alina Finch, Chiara Bardella, Georgios Solomou, Asim Asghar
| MDPI
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
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Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors - Nature Communications

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By Raphael Reinbold, Patrick Rabe, Ryan A. Herold, Alina Finch, James Wood, Melissa Morgan, Ian J. Clifton, Fraser A. Armstrong, Chiara Bardella, Christopher J Schofield, Ingvild C. Hvinden, Maximillian Staudt
| Nature Verified
Abstract Ivosidenib, an inhibitor of isocitrate dehydrogenase 1 (IDH1) R132C and R132H variants, is approved for the treatment of acute myeloid leukaemia (AML). Resistance to ivosidenib due to a second site mutation of IDH1 R132C, leading to IDH1 R132C/S280F, has emerged.
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Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis

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By Chiara Bardella, Kate E. R. Hollinshead, Haydn Munford, Katherine L. Eales
| Cell Press Verified
Enhanced Proline Synthesis in IDH1-Mutated Cells Is Mediated through PYCR1   Increased PYCR1 Expression and Proline Synthesis Is Observed in IDH1-Mutated Gliomas We therefore examined whether IDH1 mutant cells demonstrated altered proline biosynthetic enzyme expression. Proline is synthesized from glutamate in two steps; pyrroline 5-carboxylate (P5C) synthase (encoded by ALDH18A1) followed by either of two P5C reductases (PYCR1 and PYCR2; Figure 1Figure 1E).
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