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Addendum: Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche
Addendum to: Nature Medicine https://doi.org/10.1038/nm.3750, published online 1 December 2014. In the version of this article initially published, we reported paired immunohistochemical staining of Ki67 and CDKN2A/p16INK4A on serial sections of Vil1-Grem1 mouse polyps (Fig. 2e) and human traditional serrated adenomas (TSAs; Supplementary Fig. 7d), which we interpreted as showing loss of CDKN2A/p16INK4A expression in proliferating ectopic crypt cells.
Mutant IDH in Gliomas: Role in Cancer and Treatment Options
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors - Nature Communications
Abstract Ivosidenib, an inhibitor of isocitrate dehydrogenase 1 (IDH1) R132C and R132H variants, is approved for the treatment of acute myeloid leukaemia (AML). Resistance to ivosidenib due to a second site mutation of IDH1 R132C, leading to IDH1 R132C/S280F, has emerged.
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