Chiara Bartolucci

Abstract Aims The resolution of inflammation is modulated by specialized pro-resolving lipid mediators (SPMs), which can be modified in some cardiovascular diseases. Among them, RvD1 and LXA4 prevent atrial fibrillation (AF) remodeling in the atria and cardiac hypertrophy, respectively in animal models. However, little is known about their electrophysiological effects on cardiac voltage-gated (VG) ion channels.

Introduction Since its discovery by Sunao Tawara and Karl Albert Aschoff in 1906 (Cavero & Holzgrefe, 2022), the atrioventricular node (AVN) (named, at that time, ‘Aschoff-Tawara node’) has been identified as a key component of the cardiac pacemaker-conduction system in mammalian hearts. The primary function of the AVN is to conduct the action potential from the atria to the ventricles, being normally the sole pathway for impulse propagation between them.

Abstract Human induced pluripotent stem cells-derived cardiomyocytes have revolutionized the field of regenerative medicine, offering unparalleled potential for in-vitro modeling of normal and pathological human cardiomyocytes. The ability to produce stem cardiac myocytes in abundance has opened new avenues for drug efficacy and safety testing, as well as the study of conditions such as atrial fibrillation, a familial cardiac disorder.