Chiung-Ying Chang

Highlights • ACTL6A occupancy in the BAF complex is substoichiometric in normal epithelial cells • SCC cells upregulate ACTL6A, thus increasing ACTL6A assembly with the BAF complex • ACTL6A mediates co-dependent chromatin loading of BAF and TEAD-YAP complexes • ACTL6A upregulation counteracts polycomb-mediated repression at SCC signature genes Summary Mammalian SWI/SNF (BAF) chromatin remodelers play dosage-sensitive roles in many human malignancies and neurologic disorders.

Research Article Yuan-Hung Lo, Kevin S. Kolahi, Yuhong Du, Chiung-Ying Chang, Andrey Krokhotin, Ajay Nair, Walter D. Sobba, Kasper Karlsson, Sunny J. Jones, Teri A Longacre, Amanda T. Mah, Bahar Tercan, Alexandra Sockell, Hang Xu, Jose A Seoane, Jin Chen, Ilya Shmulevich, Jonathan S. Weissman, Christina Curtis, Andrea Califano, Haian Fu, Gerald R. Crabtree and Calvin J. Kuo DOI: 10.1158/2159-8290.CD-20-1109 Abstract Mutations in ARID1A rank amongst the most common molecular aberrations in human cancer.

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