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Chongbiao Huang on Muck Rack

Chongbiao Huang

As seen in: Nature, Cell Press, Texas Medical Center
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Articles

Targeting TNK2/ACK1 reverses the immunosuppressive tumor microenvironment and synergizes with immunochemotherapy in pancreatic cancer - Nature Communications

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By Nan Wang, Jun Yu, Peiqing Sun, Chongbiao Huang, Antao Chang
| Nature Verified
Abstract Pancreatic ductal adenocarcinoma (PDAC) remains highly lethal due to its aggressive nature and limited treatment options, with the efficacy of immunotherapy constrained by a uniquely immunosuppressive tumor microenvironment (TME). In this study, we identify TNK2/ACK1 as a key regulator of the immunosuppressive TME in PDAC. TNK2/ACK1 is significantly upregulated in PDAC, at least in part via gene amplification and KRAS-G12 mutations.
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"BICC1 Drives Pancreatic Cancer Progression by Inducing VEGF-Independen" by Chongbiao Huang, Hui Li et al.

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By Chongbiao Huang, Hui Li, Yang Xu, Chao Xu
| Texas Medical Center
Abstract VEGF inhibitors are one of the most successful antiangiogenic drugs in the treatment of many solid tumors. Nevertheless, pancreatic adenocarcinoma (PAAD) cells can reinstate tumor angiogenesis via activation of VEGF-independent pathways, thereby conferring resistance to VEGF inhibitors. Bioinformatic analysis showed that BICC1 was one of the top genes involved in the specific angiogenesis process of PAAD.
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Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments

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By Shengchen Lin, Chongbiao Huang, Venugopal Gunda, Jianwei Sun
| pubpeer.com
Comment Cell Reports (2019) - pubmed: 31509745 doi: 10.1016/j.celrep.2019.08.011 issn: 2211-1247 Shengchen Lin, Chongbiao Huang, Venugopal Gunda, Jianwei Sun, Srikumar P. Chellappan, Zengxun Li, Victoria Izumi, Bin Fang, John Koomen, Pankaj K. Singh, Jihui Hao, Shengyu Yang
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