Chonghai Yin

Abstract Elucidating how microscale molecular architecture shapes macroscale brain network organization requires integrative frameworks that link transcriptional profiles, structural connectivity, and functional dynamics across scales. However, existing evidence largely relies on cross-modal data acquired from different individuals, limiting causal and mechanistic inference.

Highlights • DCX ferrets mimic human lissencephaly syndrome • DCX is crucial for NPC proliferation and fiber extension • Atlas of lissencephalic cortex via snRNA-seq • Specific coupling of inhibitory to excitatory neurons Summary Lissencephaly is a rare brain malformation for which our understanding remains limited due to the absence of suitable animal models that accurately represent human phenotypes.