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Articles

Association of central serous chorioretinopathy with single-nucleotide polymorphisms in Complement Factor H gene in a Chinese population - International Ophthalmology

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By Choroid Diseases
| link.springer.com
Abstract To analyze the association between central serous chorioretinopathy (CSCR) and single-nucleotide polymorphisms in the complement factor H (CFH) gene in patients of Chinese descent. We genotyped each patient for six single-nucleotide polymorphism (SNP) markers in CFH (rs800292, rs1061170, rs3753396, rs2284664, rs1329428, and rs1065489), and assessed each SNP’s associations with CSCR.
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Serum lipids mediate the association of per- and polyfluoroalkyl substances exposure and age-related macular degeneration

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By Xiaodong Chen, Eye diseases, Choroid Diseases, Jiaqi Li
| PLOS ONE
Citation: Chen X, Li J, Xu N, Li X, Li J, Guo Q, et al. (2025) Serum lipids mediate the association of per- and polyfluoroalkyl substances exposure and age-related macular degeneration. PLoS ONE 20(1): e0317678. https://doi.org/10.1371/journal.pone.0317678 Editor: Linglin Xie, Texas A&M University College Station, UNITED STATES OF AMERICA Received: September 26, 2024; Accepted: January 2, 2025; Published: January 31, 2025 Copyright: © 2025 Chen et al.
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Splice Variant of Retinal G-Protein-Coupled Receptor Deletion-Mediated Dysregulation of Autophagy Increases the Susceptibility to Age-Related Macular Degeneration-Like Defects

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By Eye diseases, Choroid Diseases, Ng SY
| karger.com
Keywords: Age-related macular degeneration, Retinal G-protein-coupled receptor deletion, Autophagy Age-related macular degeneration (AMD) is one of the most common causes of severe, irreversible vision loss. Dysregulation of the inflammatory system, complement pathway, lipid signaling, angiogenesis, and extracellular matrix are involved in the development of AMD [1]. It has been estimated that 288 million people worldwide will have AMD by 2040 [2].
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