X @NambaShinichi Contributors CK, SM and ST designed the study and acquired samples from patients. CK analysed the data and performed statistical analyses. CK, SM, ST, SN, QW, YO and HO contributed to the interpretation of the results. ST, SN, QW, YO and HO provided supervision. CK and SM wrote the manuscript, and all authors corrected the manuscript and collectively made the decision to submit for publication.