Christina Stephens on Muck Rack

Christina Stephens

Baton Rouge
As seen in: Medium, Mom.com, The Advocate (Baton Rouge, LA), eLife, And The Valley Shook
Public Relations + Crisis Comms • Formerly @LouisianaGov • Baby Runner 🏃🏻‍♀️• Leopard Print is Not Tiger Stripes • Lover of the Louisiana Life • LSU
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Articles

Transition Path Sampling Guided by Structural Motifs

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By Christina Stephens, John M. Rosenberg, Michael Grabe, YooJin C. Sheen
| dx.doi.org
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Simulation-based survey of TMEM16 family reveals that robust lipid scrambling requires an open groove

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By Christina Stephens, Niek van Hilten, Lisa Zheng, Michael Grabe
| eLife
eLife Assessment This important study provides information on the TMEM16 family of membrane proteins, which play roles in lipid scrambling and ion transport. By simulating 27 structures representing five distinct family members, the authors captured hundreds of lipid scrambling events, offering insights into the mechanisms of lipid translocation and the specific protein regions involved in these processes.
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Simulation-based survey of TMEM16 family reveals that robust lipid scrambling requires an open groove

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By Christina Stephens, Niek van Hilten, Lisa Zheng, Michael Grabe
| biorxiv.org
Abstract Biological membranes are complex and dynamic structures with different populations of lipids in their inner and outer leaflets. The Ca2+-activated TMEM16 family of membrane proteins plays an important role in collapsing this asymmetric lipid distribution by spontaneously, and bidirectionally, scrambling phospholipids between the two leaflets, which can initiate signaling and alter the physical properties of the membrane.
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