Christina Wade

Abstract Background A polygenic risk score (PRS) enables personalisation of cancer risk and supporting risk stratification for melanoma, colorectal, breast, and prostate cancers. Including a PRS in a cancer risk assessment can facilitate risk-appropriate cancer screening by incorporating an individual’s age, sex, family history, and genomic test results. GPs are the likely healthcare professionals to order PRS tests and deliver results to patients within existing preventative health models.

Reflexive thematic analysis, with a mixed inductive and deductive approach, was used to analyse the interview data.31 Interviews were conducted by five authors in their capacity as a research assistant, Master’s student, or PhD student. All interviewers had regular supervision to discuss and reflect on the content raised, the context of the interview (within an overarching trial or with GPs who were PRS naive), and the approach of the interviewer themselves.

Abstract Background: Polygenic Risk Scores (PRSs) enable personalisation of cancer risk, supporting risk stratification for melanoma, and colorectal, breast, and prostate cancers. Inclusion of PRS in cancer risk assessment can facilitate risk-appropriate cancer screening by incorporating individuals’ age, sex, family history and genomic test results.